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Association between the platelet‐lymphocyte ratio and short‐term mortality in patients with non‐ST‐segment elevation myocardial infarction

BACKGROUND: Previous studies have shown that inflammation plays an important role in atherosclerosis and cardiovascular disease. Platelet to lymphocyte ratio (PLR) has been reported as a novel inflammatory marker. However, it is not clear whether PLR is associated with short‐term all‐cause mortality...

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Autores principales: Meng, Zhongyuan, Yang, Jiaqiang, Wu, Jianfu, Zheng, Xifeng, Zhao, Yaxin, He, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Periodicals, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259151/
https://www.ncbi.nlm.nih.gov/pubmed/34037246
http://dx.doi.org/10.1002/clc.23648
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author Meng, Zhongyuan
Yang, Jiaqiang
Wu, Jianfu
Zheng, Xifeng
Zhao, Yaxin
He, Yan
author_facet Meng, Zhongyuan
Yang, Jiaqiang
Wu, Jianfu
Zheng, Xifeng
Zhao, Yaxin
He, Yan
author_sort Meng, Zhongyuan
collection PubMed
description BACKGROUND: Previous studies have shown that inflammation plays an important role in atherosclerosis and cardiovascular disease. Platelet to lymphocyte ratio (PLR) has been reported as a novel inflammatory marker. However, it is not clear whether PLR is associated with short‐term all‐cause mortality in critically ill patients with non‐ST‐segment elevation myocardial infarction (NSTEMI). METHODS: The data for the study is from the Medical Information Mart for Intensive Care III database. The primary outcome in our study was 28‐day mortality. Kapan‐Meier curve, lowess smoother curve, and multivariate Cox regression models were used to determine whether the association between PLR and 28‐day mortality of critically ill patients with NSTEMI. RESULTS: A total of 1273 critically ill patients with NSTEMI were included in this analysis. Kapan‐Meier curve and lowess smoother curve show that high PLR is associated with an increased risk of 28‐day all‐cause mortality. The study population is divided into two groups according to the cut‐off value of PLR level. In the Cox model, high PLR levels (PLR≥195.8) were significantly associated with increased 28‐day mortality (HR 1.54; 95%CI 1.09–2.18, p = .013). In quartile analyses, the HR (95% CI) for the third (183 ≤ PLR < 306) and fourth quartile (PLR≥306) was 1.55 (1.05–2.29) and 1.61 (1.03–2.52), respectively, compared to the reference group(111 ≤ PLR < 183). In subgroup analyses, there is no interaction effect in most of the subgroups except for respiratory failure and vasopressor use. CONCLUSION: High PLR is associated with an increased risk of short‐term mortality in critically ill patients with NSTEMI.
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spelling pubmed-82591512021-07-12 Association between the platelet‐lymphocyte ratio and short‐term mortality in patients with non‐ST‐segment elevation myocardial infarction Meng, Zhongyuan Yang, Jiaqiang Wu, Jianfu Zheng, Xifeng Zhao, Yaxin He, Yan Clin Cardiol Clinical Investigations BACKGROUND: Previous studies have shown that inflammation plays an important role in atherosclerosis and cardiovascular disease. Platelet to lymphocyte ratio (PLR) has been reported as a novel inflammatory marker. However, it is not clear whether PLR is associated with short‐term all‐cause mortality in critically ill patients with non‐ST‐segment elevation myocardial infarction (NSTEMI). METHODS: The data for the study is from the Medical Information Mart for Intensive Care III database. The primary outcome in our study was 28‐day mortality. Kapan‐Meier curve, lowess smoother curve, and multivariate Cox regression models were used to determine whether the association between PLR and 28‐day mortality of critically ill patients with NSTEMI. RESULTS: A total of 1273 critically ill patients with NSTEMI were included in this analysis. Kapan‐Meier curve and lowess smoother curve show that high PLR is associated with an increased risk of 28‐day all‐cause mortality. The study population is divided into two groups according to the cut‐off value of PLR level. In the Cox model, high PLR levels (PLR≥195.8) were significantly associated with increased 28‐day mortality (HR 1.54; 95%CI 1.09–2.18, p = .013). In quartile analyses, the HR (95% CI) for the third (183 ≤ PLR < 306) and fourth quartile (PLR≥306) was 1.55 (1.05–2.29) and 1.61 (1.03–2.52), respectively, compared to the reference group(111 ≤ PLR < 183). In subgroup analyses, there is no interaction effect in most of the subgroups except for respiratory failure and vasopressor use. CONCLUSION: High PLR is associated with an increased risk of short‐term mortality in critically ill patients with NSTEMI. Wiley Periodicals, Inc. 2021-05-26 /pmc/articles/PMC8259151/ /pubmed/34037246 http://dx.doi.org/10.1002/clc.23648 Text en © 2021 The Authors. Clinical Cardiology published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Investigations
Meng, Zhongyuan
Yang, Jiaqiang
Wu, Jianfu
Zheng, Xifeng
Zhao, Yaxin
He, Yan
Association between the platelet‐lymphocyte ratio and short‐term mortality in patients with non‐ST‐segment elevation myocardial infarction
title Association between the platelet‐lymphocyte ratio and short‐term mortality in patients with non‐ST‐segment elevation myocardial infarction
title_full Association between the platelet‐lymphocyte ratio and short‐term mortality in patients with non‐ST‐segment elevation myocardial infarction
title_fullStr Association between the platelet‐lymphocyte ratio and short‐term mortality in patients with non‐ST‐segment elevation myocardial infarction
title_full_unstemmed Association between the platelet‐lymphocyte ratio and short‐term mortality in patients with non‐ST‐segment elevation myocardial infarction
title_short Association between the platelet‐lymphocyte ratio and short‐term mortality in patients with non‐ST‐segment elevation myocardial infarction
title_sort association between the platelet‐lymphocyte ratio and short‐term mortality in patients with non‐st‐segment elevation myocardial infarction
topic Clinical Investigations
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259151/
https://www.ncbi.nlm.nih.gov/pubmed/34037246
http://dx.doi.org/10.1002/clc.23648
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