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Inflammation-related genes S100s, RNASE3, and CYBB and risk of leukemic transformation in patients with myelodysplastic syndrome with myelofibrosis
Myelodysplastic syndrome with myelofibrosis (MDS-MF) has been associated with an inferior prognosis compared with MDS without MF. However, MDS-MF is not listed independently as a subtype of MDS, and its clinical and genetic characteristics remain poorly understood. We retrospectively compared 53 pat...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259211/ https://www.ncbi.nlm.nih.gov/pubmed/34229751 http://dx.doi.org/10.1186/s40364-021-00304-w |
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author | Hong, Minghua Wu, Junqing Ma, Lifeng Han, Xiaoping Lu, Ting Wang, Zhaoming Zhao, Jing Liu, Lizhen Fu, Huarui Huang, Weijia Zheng, Weiyan He, Jingsong Wei, Guoqing Wang, Huanping Chen, Zhimei Huang, He Cai, Zhen Guo, Guoji Sun, Jie |
author_facet | Hong, Minghua Wu, Junqing Ma, Lifeng Han, Xiaoping Lu, Ting Wang, Zhaoming Zhao, Jing Liu, Lizhen Fu, Huarui Huang, Weijia Zheng, Weiyan He, Jingsong Wei, Guoqing Wang, Huanping Chen, Zhimei Huang, He Cai, Zhen Guo, Guoji Sun, Jie |
author_sort | Hong, Minghua |
collection | PubMed |
description | Myelodysplastic syndrome with myelofibrosis (MDS-MF) has been associated with an inferior prognosis compared with MDS without MF. However, MDS-MF is not listed independently as a subtype of MDS, and its clinical and genetic characteristics remain poorly understood. We retrospectively compared 53 patients with MDS-MF (44 MF grade 1/MF(1); 9 MF grade 2–3/MF(2 − 3)) and 31 with de novo MDS without MF (MDS). The leukemic transformation risks of both MDS-MF(2 − 3) and MDS-MF(1) were increased compared with the MDS group. To identify the potential mechanisms responsible for the leukemic transformation of MDS-MF, we performed single-cell sequencing for one MDS-MF(2 − 3) patient before and after leukemic transformation to explore the variations in gene expression levels. In addition to upgraded expression levels of acute myeloid leukemia-related genes during leukemic transformation, expression levels of some inflammation-related genes (such as S100s, RNASE3, and CYBB) were also increased, and inflammation-related pathways were up-regulated. These results suggest that inflammation-related genes and pathways may play an important role in the leukemic transformation of MDS-MF. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40364-021-00304-w. |
format | Online Article Text |
id | pubmed-8259211 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-82592112021-07-06 Inflammation-related genes S100s, RNASE3, and CYBB and risk of leukemic transformation in patients with myelodysplastic syndrome with myelofibrosis Hong, Minghua Wu, Junqing Ma, Lifeng Han, Xiaoping Lu, Ting Wang, Zhaoming Zhao, Jing Liu, Lizhen Fu, Huarui Huang, Weijia Zheng, Weiyan He, Jingsong Wei, Guoqing Wang, Huanping Chen, Zhimei Huang, He Cai, Zhen Guo, Guoji Sun, Jie Biomark Res Letter to the Editor Myelodysplastic syndrome with myelofibrosis (MDS-MF) has been associated with an inferior prognosis compared with MDS without MF. However, MDS-MF is not listed independently as a subtype of MDS, and its clinical and genetic characteristics remain poorly understood. We retrospectively compared 53 patients with MDS-MF (44 MF grade 1/MF(1); 9 MF grade 2–3/MF(2 − 3)) and 31 with de novo MDS without MF (MDS). The leukemic transformation risks of both MDS-MF(2 − 3) and MDS-MF(1) were increased compared with the MDS group. To identify the potential mechanisms responsible for the leukemic transformation of MDS-MF, we performed single-cell sequencing for one MDS-MF(2 − 3) patient before and after leukemic transformation to explore the variations in gene expression levels. In addition to upgraded expression levels of acute myeloid leukemia-related genes during leukemic transformation, expression levels of some inflammation-related genes (such as S100s, RNASE3, and CYBB) were also increased, and inflammation-related pathways were up-regulated. These results suggest that inflammation-related genes and pathways may play an important role in the leukemic transformation of MDS-MF. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40364-021-00304-w. BioMed Central 2021-07-02 /pmc/articles/PMC8259211/ /pubmed/34229751 http://dx.doi.org/10.1186/s40364-021-00304-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Letter to the Editor Hong, Minghua Wu, Junqing Ma, Lifeng Han, Xiaoping Lu, Ting Wang, Zhaoming Zhao, Jing Liu, Lizhen Fu, Huarui Huang, Weijia Zheng, Weiyan He, Jingsong Wei, Guoqing Wang, Huanping Chen, Zhimei Huang, He Cai, Zhen Guo, Guoji Sun, Jie Inflammation-related genes S100s, RNASE3, and CYBB and risk of leukemic transformation in patients with myelodysplastic syndrome with myelofibrosis |
title | Inflammation-related genes S100s, RNASE3, and CYBB and risk of leukemic transformation in patients with myelodysplastic syndrome with myelofibrosis |
title_full | Inflammation-related genes S100s, RNASE3, and CYBB and risk of leukemic transformation in patients with myelodysplastic syndrome with myelofibrosis |
title_fullStr | Inflammation-related genes S100s, RNASE3, and CYBB and risk of leukemic transformation in patients with myelodysplastic syndrome with myelofibrosis |
title_full_unstemmed | Inflammation-related genes S100s, RNASE3, and CYBB and risk of leukemic transformation in patients with myelodysplastic syndrome with myelofibrosis |
title_short | Inflammation-related genes S100s, RNASE3, and CYBB and risk of leukemic transformation in patients with myelodysplastic syndrome with myelofibrosis |
title_sort | inflammation-related genes s100s, rnase3, and cybb and risk of leukemic transformation in patients with myelodysplastic syndrome with myelofibrosis |
topic | Letter to the Editor |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259211/ https://www.ncbi.nlm.nih.gov/pubmed/34229751 http://dx.doi.org/10.1186/s40364-021-00304-w |
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