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Binding of single-mutant epidermal growth factor (EGF) ligands alters the stability of the EGF receptor dimer and promotes growth signaling

The epidermal growth factor receptor (EGFR) is a membrane-anchored tyrosine kinase that is able to selectively respond to multiple extracellular stimuli. Previous studies have indicated that the modularity of this system may be caused by ligand-induced differences in the stability of the receptor di...

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Detalles Bibliográficos
Autores principales:	Pascarelli, Stefano, Merzhakupova, Dalmira, Uechi, Gen-Ichiro, Laurino, Paola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259408/ https://www.ncbi.nlm.nih.gov/pubmed/34126069 http://dx.doi.org/10.1016/j.jbc.2021.100872

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