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Discovery Genome-Wide Association Study of Body Composition in 4,386 Adults From the UK Biobank’s Pilot Imaging Enhancement Study

Body composition (fat, skeletal muscle and bone mass) is an important determinant of overall health and risk of endocrine disorders such as type 2 diabetes and osteoporosis. Although diet and physical activity are strongly implicated, body composition is also heritable. We conducted a discovery geno...

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Autores principales: Livingstone, Katherine M., Tan, Mun Hua, Abbott, Gavin, Duckham, Rachel L., Croft, Larry, Ward, Joey, McEvoy, Mark, Keske, Michelle A., Austin, Christopher, Bowe, Steven J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259458/
https://www.ncbi.nlm.nih.gov/pubmed/34239500
http://dx.doi.org/10.3389/fendo.2021.692677
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author Livingstone, Katherine M.
Tan, Mun Hua
Abbott, Gavin
Duckham, Rachel L.
Croft, Larry
Ward, Joey
McEvoy, Mark
Keske, Michelle A.
Austin, Christopher
Bowe, Steven J.
author_facet Livingstone, Katherine M.
Tan, Mun Hua
Abbott, Gavin
Duckham, Rachel L.
Croft, Larry
Ward, Joey
McEvoy, Mark
Keske, Michelle A.
Austin, Christopher
Bowe, Steven J.
author_sort Livingstone, Katherine M.
collection PubMed
description Body composition (fat, skeletal muscle and bone mass) is an important determinant of overall health and risk of endocrine disorders such as type 2 diabetes and osteoporosis. Although diet and physical activity are strongly implicated, body composition is also heritable. We conducted a discovery genome-wide association study on 31 phenotypes from the three-compartment body composition model (fat, lean and bone mass) in a set of 4 386 individuals (n = 2 109 males, n = 2 294 females) from the UK Biobank pilot imaging enhancement program that underwent a dual energy X-ray absorptiometry (DXA) scan for assessment of body composition and genetic screening. From 6 137 607 imputed single nucleotide polymorphisms (SNPs) we identified 17 body composition loci (P<5.0 x 10-8). GWAS from the combined dataset identified four statistically significant SNPs (rs7592270, rs145972737, rs13212044, rs77772562). In sex-stratified GWAS, 10 male specific SNPs across all traits were identified and five female specific SNPs. Of the 17 SNPs, six were in or close to a gene where there was a plausible functional connection. Three SNPs (rs7592270, rs77772562 and rs7552312) were correlated with obesity phenotypes, one SNP (rs2236705) with lean phenotypes and two with bone mass phenotypes (rs112098641 and rs113380185). These results highlight candidate genes and biological pathways related to body composition, including glucose metabolism and estrogen regulation, that are of interest to replicate in future studies.
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spelling pubmed-82594582021-07-07 Discovery Genome-Wide Association Study of Body Composition in 4,386 Adults From the UK Biobank’s Pilot Imaging Enhancement Study Livingstone, Katherine M. Tan, Mun Hua Abbott, Gavin Duckham, Rachel L. Croft, Larry Ward, Joey McEvoy, Mark Keske, Michelle A. Austin, Christopher Bowe, Steven J. Front Endocrinol (Lausanne) Endocrinology Body composition (fat, skeletal muscle and bone mass) is an important determinant of overall health and risk of endocrine disorders such as type 2 diabetes and osteoporosis. Although diet and physical activity are strongly implicated, body composition is also heritable. We conducted a discovery genome-wide association study on 31 phenotypes from the three-compartment body composition model (fat, lean and bone mass) in a set of 4 386 individuals (n = 2 109 males, n = 2 294 females) from the UK Biobank pilot imaging enhancement program that underwent a dual energy X-ray absorptiometry (DXA) scan for assessment of body composition and genetic screening. From 6 137 607 imputed single nucleotide polymorphisms (SNPs) we identified 17 body composition loci (P<5.0 x 10-8). GWAS from the combined dataset identified four statistically significant SNPs (rs7592270, rs145972737, rs13212044, rs77772562). In sex-stratified GWAS, 10 male specific SNPs across all traits were identified and five female specific SNPs. Of the 17 SNPs, six were in or close to a gene where there was a plausible functional connection. Three SNPs (rs7592270, rs77772562 and rs7552312) were correlated with obesity phenotypes, one SNP (rs2236705) with lean phenotypes and two with bone mass phenotypes (rs112098641 and rs113380185). These results highlight candidate genes and biological pathways related to body composition, including glucose metabolism and estrogen regulation, that are of interest to replicate in future studies. Frontiers Media S.A. 2021-06-22 /pmc/articles/PMC8259458/ /pubmed/34239500 http://dx.doi.org/10.3389/fendo.2021.692677 Text en Copyright © 2021 Livingstone, Tan, Abbott, Duckham, Croft, Ward, McEvoy, Keske, Austin and Bowe https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Livingstone, Katherine M.
Tan, Mun Hua
Abbott, Gavin
Duckham, Rachel L.
Croft, Larry
Ward, Joey
McEvoy, Mark
Keske, Michelle A.
Austin, Christopher
Bowe, Steven J.
Discovery Genome-Wide Association Study of Body Composition in 4,386 Adults From the UK Biobank’s Pilot Imaging Enhancement Study
title Discovery Genome-Wide Association Study of Body Composition in 4,386 Adults From the UK Biobank’s Pilot Imaging Enhancement Study
title_full Discovery Genome-Wide Association Study of Body Composition in 4,386 Adults From the UK Biobank’s Pilot Imaging Enhancement Study
title_fullStr Discovery Genome-Wide Association Study of Body Composition in 4,386 Adults From the UK Biobank’s Pilot Imaging Enhancement Study
title_full_unstemmed Discovery Genome-Wide Association Study of Body Composition in 4,386 Adults From the UK Biobank’s Pilot Imaging Enhancement Study
title_short Discovery Genome-Wide Association Study of Body Composition in 4,386 Adults From the UK Biobank’s Pilot Imaging Enhancement Study
title_sort discovery genome-wide association study of body composition in 4,386 adults from the uk biobank’s pilot imaging enhancement study
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259458/
https://www.ncbi.nlm.nih.gov/pubmed/34239500
http://dx.doi.org/10.3389/fendo.2021.692677
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