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Ocular surface disorder among adult patients with type II diabetes mellitus and its correlation with tear film markers: A pilot study

PURPOSE: The purpose is to study the ocular surface changes among patients with diabetes mellitus (DM) and to correlate them with tear film markers such as insulin-like growth factor (IGF)-1, interleukin (IL)-1β, and tumor necrosis factor (TNF)-α levels. MATERIALS AND METHODS: The study was carried...

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Autores principales: Manchikanti, Vijayakumari, Kasturi, Nirupama, Rajappa, Medha, Gochhait, Debasis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259518/
https://www.ncbi.nlm.nih.gov/pubmed/34295621
http://dx.doi.org/10.4103/tjo.tjo_56_20
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author Manchikanti, Vijayakumari
Kasturi, Nirupama
Rajappa, Medha
Gochhait, Debasis
author_facet Manchikanti, Vijayakumari
Kasturi, Nirupama
Rajappa, Medha
Gochhait, Debasis
author_sort Manchikanti, Vijayakumari
collection PubMed
description PURPOSE: The purpose is to study the ocular surface changes among patients with diabetes mellitus (DM) and to correlate them with tear film markers such as insulin-like growth factor (IGF)-1, interleukin (IL)-1β, and tumor necrosis factor (TNF)-α levels. MATERIALS AND METHODS: The study was carried out on diabetic patients (>5 years' duration) and healthy age- and gender-matched controls with 21 individuals in each group. Schirmer's test for basal and reflex tear secretion, tear film breakup time (TBUT) for tear stability, ocular staining score (OSS) for dryness severity, ocular surface disease index (OSDI) for symptomatic assessment of dryness and conjunctival impression cytology (IC) for epithelial cell integrity, keratinization, squamous metaplasia, and goblet cell density was studied. Thirty microliters of tears were collected to test IGF-1, IL-1β, and TNF-α levels. RESULTS: Patients with DM showed significantly low Schirmer's, TBUT, and OSS values than controls. OSDI score showed moderate-severe dryness in patients with DM and only mild symptoms among controls. An abnormal IC score was seen among cases and controls. The level of TNF-α was significantly increased in patients with DM and positively correlated with Schirmer and TBUT values (P < 0.05). CONCLUSION: Dry eye is more prevalent in patients with DM compared to controls as evidenced by poor OSDI score, Schirmer, TBUT, and OSS. TNF-α in the tears of patients with DM is a useful marker that showed a good correlation with Schirmer, TBUT, and dry eye symptoms. IC could not conclusively differentiate the dry eye status in patients with DM from controls.
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spelling pubmed-82595182021-07-21 Ocular surface disorder among adult patients with type II diabetes mellitus and its correlation with tear film markers: A pilot study Manchikanti, Vijayakumari Kasturi, Nirupama Rajappa, Medha Gochhait, Debasis Taiwan J Ophthalmol Original Article PURPOSE: The purpose is to study the ocular surface changes among patients with diabetes mellitus (DM) and to correlate them with tear film markers such as insulin-like growth factor (IGF)-1, interleukin (IL)-1β, and tumor necrosis factor (TNF)-α levels. MATERIALS AND METHODS: The study was carried out on diabetic patients (>5 years' duration) and healthy age- and gender-matched controls with 21 individuals in each group. Schirmer's test for basal and reflex tear secretion, tear film breakup time (TBUT) for tear stability, ocular staining score (OSS) for dryness severity, ocular surface disease index (OSDI) for symptomatic assessment of dryness and conjunctival impression cytology (IC) for epithelial cell integrity, keratinization, squamous metaplasia, and goblet cell density was studied. Thirty microliters of tears were collected to test IGF-1, IL-1β, and TNF-α levels. RESULTS: Patients with DM showed significantly low Schirmer's, TBUT, and OSS values than controls. OSDI score showed moderate-severe dryness in patients with DM and only mild symptoms among controls. An abnormal IC score was seen among cases and controls. The level of TNF-α was significantly increased in patients with DM and positively correlated with Schirmer and TBUT values (P < 0.05). CONCLUSION: Dry eye is more prevalent in patients with DM compared to controls as evidenced by poor OSDI score, Schirmer, TBUT, and OSS. TNF-α in the tears of patients with DM is a useful marker that showed a good correlation with Schirmer, TBUT, and dry eye symptoms. IC could not conclusively differentiate the dry eye status in patients with DM from controls. Wolters Kluwer - Medknow 2020-10-08 /pmc/articles/PMC8259518/ /pubmed/34295621 http://dx.doi.org/10.4103/tjo.tjo_56_20 Text en Copyright: © 2020 Taiwan J Ophthalmol https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Manchikanti, Vijayakumari
Kasturi, Nirupama
Rajappa, Medha
Gochhait, Debasis
Ocular surface disorder among adult patients with type II diabetes mellitus and its correlation with tear film markers: A pilot study
title Ocular surface disorder among adult patients with type II diabetes mellitus and its correlation with tear film markers: A pilot study
title_full Ocular surface disorder among adult patients with type II diabetes mellitus and its correlation with tear film markers: A pilot study
title_fullStr Ocular surface disorder among adult patients with type II diabetes mellitus and its correlation with tear film markers: A pilot study
title_full_unstemmed Ocular surface disorder among adult patients with type II diabetes mellitus and its correlation with tear film markers: A pilot study
title_short Ocular surface disorder among adult patients with type II diabetes mellitus and its correlation with tear film markers: A pilot study
title_sort ocular surface disorder among adult patients with type ii diabetes mellitus and its correlation with tear film markers: a pilot study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259518/
https://www.ncbi.nlm.nih.gov/pubmed/34295621
http://dx.doi.org/10.4103/tjo.tjo_56_20
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