A multicomponent tetrazolo indole synthesis

The ubiquitous presence of the indole fragment in natural products and drugs asks for ever novel syntheses. We report an unprecedented mild, two-step synthesis of 2-tetrazolo substituted indoles based on the Ugi-tetrazole reaction combined with an acidic ring closure. A gram-scale synthesis, a bioac...

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Detalles Bibliográficos
Autores principales: Lei, Xiaofang, Lampiri, Panagiota, Patil, Pravin, Angeli, Giasemi, Neochoritis, Constantinos G., Dömling, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259579/
https://www.ncbi.nlm.nih.gov/pubmed/34128009
http://dx.doi.org/10.1039/d1cc02384e
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author Lei, Xiaofang
Lampiri, Panagiota
Patil, Pravin
Angeli, Giasemi
Neochoritis, Constantinos G.
Dömling, Alexander
author_facet Lei, Xiaofang
Lampiri, Panagiota
Patil, Pravin
Angeli, Giasemi
Neochoritis, Constantinos G.
Dömling, Alexander
author_sort Lei, Xiaofang
collection PubMed
description The ubiquitous presence of the indole fragment in natural products and drugs asks for ever novel syntheses. We report an unprecedented mild, two-step synthesis of 2-tetrazolo substituted indoles based on the Ugi-tetrazole reaction combined with an acidic ring closure. A gram-scale synthesis, a bioactive compound and further transformations were performed.
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spelling pubmed-82595792021-07-16 A multicomponent tetrazolo indole synthesis Lei, Xiaofang Lampiri, Panagiota Patil, Pravin Angeli, Giasemi Neochoritis, Constantinos G. Dömling, Alexander Chem Commun (Camb) Chemistry The ubiquitous presence of the indole fragment in natural products and drugs asks for ever novel syntheses. We report an unprecedented mild, two-step synthesis of 2-tetrazolo substituted indoles based on the Ugi-tetrazole reaction combined with an acidic ring closure. A gram-scale synthesis, a bioactive compound and further transformations were performed. The Royal Society of Chemistry 2021-06-09 /pmc/articles/PMC8259579/ /pubmed/34128009 http://dx.doi.org/10.1039/d1cc02384e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Lei, Xiaofang
Lampiri, Panagiota
Patil, Pravin
Angeli, Giasemi
Neochoritis, Constantinos G.
Dömling, Alexander
A multicomponent tetrazolo indole synthesis
title A multicomponent tetrazolo indole synthesis
title_full A multicomponent tetrazolo indole synthesis
title_fullStr A multicomponent tetrazolo indole synthesis
title_full_unstemmed A multicomponent tetrazolo indole synthesis
title_short A multicomponent tetrazolo indole synthesis
title_sort multicomponent tetrazolo indole synthesis
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259579/
https://www.ncbi.nlm.nih.gov/pubmed/34128009
http://dx.doi.org/10.1039/d1cc02384e
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