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Alcohol as friend or foe in autoimmune diseases: a role for gut microbiome?
Alcohol is well known for promoting systemic inflammation and aggravating multiple chronic health conditions. Thus, alcohol may also be expected to serve as a risk factor in autoimmune diseases. However, emerging data from human and animal studies suggest that alcohol may in fact be protective in au...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259720/ https://www.ncbi.nlm.nih.gov/pubmed/34224314 http://dx.doi.org/10.1080/19490976.2021.1916278 |
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author | Caslin, Blaine Mohler, Kailey Thiagarajan, Shreya Melamed, Esther |
author_facet | Caslin, Blaine Mohler, Kailey Thiagarajan, Shreya Melamed, Esther |
author_sort | Caslin, Blaine |
collection | PubMed |
description | Alcohol is well known for promoting systemic inflammation and aggravating multiple chronic health conditions. Thus, alcohol may also be expected to serve as a risk factor in autoimmune diseases. However, emerging data from human and animal studies suggest that alcohol may in fact be protective in autoimmune diseases. These studies point toward alcohol’s complex dose-dependent relationship in autoimmune diseases as well as potential modulation by duration and type of alcohol consumption, cultural background and sex. In this review, we will explore alcohol’s pro- and anti-inflammatory properties in human and animal autoimmune diseases, including autoimmune diabetes, thyroid disease, systemic lupus erythematosus, rheumatoid arthritis, experimental autoimmune encephalomyelitis and multiple sclerosis. We will also discuss potential mechanisms of alcohol’s anti-inflammatory effects mediated by the gut microbiome. |
format | Online Article Text |
id | pubmed-8259720 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-82597202021-07-13 Alcohol as friend or foe in autoimmune diseases: a role for gut microbiome? Caslin, Blaine Mohler, Kailey Thiagarajan, Shreya Melamed, Esther Gut Microbes Review Alcohol is well known for promoting systemic inflammation and aggravating multiple chronic health conditions. Thus, alcohol may also be expected to serve as a risk factor in autoimmune diseases. However, emerging data from human and animal studies suggest that alcohol may in fact be protective in autoimmune diseases. These studies point toward alcohol’s complex dose-dependent relationship in autoimmune diseases as well as potential modulation by duration and type of alcohol consumption, cultural background and sex. In this review, we will explore alcohol’s pro- and anti-inflammatory properties in human and animal autoimmune diseases, including autoimmune diabetes, thyroid disease, systemic lupus erythematosus, rheumatoid arthritis, experimental autoimmune encephalomyelitis and multiple sclerosis. We will also discuss potential mechanisms of alcohol’s anti-inflammatory effects mediated by the gut microbiome. Taylor & Francis 2021-07-05 /pmc/articles/PMC8259720/ /pubmed/34224314 http://dx.doi.org/10.1080/19490976.2021.1916278 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Caslin, Blaine Mohler, Kailey Thiagarajan, Shreya Melamed, Esther Alcohol as friend or foe in autoimmune diseases: a role for gut microbiome? |
title | Alcohol as friend or foe in autoimmune diseases: a role for gut microbiome? |
title_full | Alcohol as friend or foe in autoimmune diseases: a role for gut microbiome? |
title_fullStr | Alcohol as friend or foe in autoimmune diseases: a role for gut microbiome? |
title_full_unstemmed | Alcohol as friend or foe in autoimmune diseases: a role for gut microbiome? |
title_short | Alcohol as friend or foe in autoimmune diseases: a role for gut microbiome? |
title_sort | alcohol as friend or foe in autoimmune diseases: a role for gut microbiome? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259720/ https://www.ncbi.nlm.nih.gov/pubmed/34224314 http://dx.doi.org/10.1080/19490976.2021.1916278 |
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