Current Progress in Investigating Mature T- and NK-Cell Lymphoma Gene Aberrations by Next-Generation Sequencing (NGS)

Despite efforts to abrogate the severe threat to life posed by the profound malignancy of mature natural killer/T-cell lymphoma (NKTCL), therapeutic advances still require further investigation of its inherent regulatory biochemical processes. Next-generation sequencing (NGS) is an increasingly deve...

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Autores principales: Zhu, Lifen, Xie, Shufang, Yang, Chen, Hua, Nanni, Wu, Yi, Wang, Lei, Ni, Wanmao, Tong, Xiangmin, Fei, Min, Wang, Shibing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259727/
https://www.ncbi.nlm.nih.gov/pubmed/34239326
http://dx.doi.org/10.2147/CMAR.S299505
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author Zhu, Lifen
Xie, Shufang
Yang, Chen
Hua, Nanni
Wu, Yi
Wang, Lei
Ni, Wanmao
Tong, Xiangmin
Fei, Min
Wang, Shibing
author_facet Zhu, Lifen
Xie, Shufang
Yang, Chen
Hua, Nanni
Wu, Yi
Wang, Lei
Ni, Wanmao
Tong, Xiangmin
Fei, Min
Wang, Shibing
author_sort Zhu, Lifen
collection PubMed
description Despite efforts to abrogate the severe threat to life posed by the profound malignancy of mature natural killer/T-cell lymphoma (NKTCL), therapeutic advances still require further investigation of its inherent regulatory biochemical processes. Next-generation sequencing (NGS) is an increasingly developing gene detection technique, which has been widely used in lymphoma genetic research in recent years. Targeted therapy based on the above studies has also generated a series of advances, making genetic mutation a new research hotspot in lymphoma. Advances in NKTCL-related gene mutations are reviewed in this paper.
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spelling pubmed-82597272021-07-07 Current Progress in Investigating Mature T- and NK-Cell Lymphoma Gene Aberrations by Next-Generation Sequencing (NGS) Zhu, Lifen Xie, Shufang Yang, Chen Hua, Nanni Wu, Yi Wang, Lei Ni, Wanmao Tong, Xiangmin Fei, Min Wang, Shibing Cancer Manag Res Review Despite efforts to abrogate the severe threat to life posed by the profound malignancy of mature natural killer/T-cell lymphoma (NKTCL), therapeutic advances still require further investigation of its inherent regulatory biochemical processes. Next-generation sequencing (NGS) is an increasingly developing gene detection technique, which has been widely used in lymphoma genetic research in recent years. Targeted therapy based on the above studies has also generated a series of advances, making genetic mutation a new research hotspot in lymphoma. Advances in NKTCL-related gene mutations are reviewed in this paper. Dove 2021-07-02 /pmc/articles/PMC8259727/ /pubmed/34239326 http://dx.doi.org/10.2147/CMAR.S299505 Text en © 2021 Zhu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Zhu, Lifen
Xie, Shufang
Yang, Chen
Hua, Nanni
Wu, Yi
Wang, Lei
Ni, Wanmao
Tong, Xiangmin
Fei, Min
Wang, Shibing
Current Progress in Investigating Mature T- and NK-Cell Lymphoma Gene Aberrations by Next-Generation Sequencing (NGS)
title Current Progress in Investigating Mature T- and NK-Cell Lymphoma Gene Aberrations by Next-Generation Sequencing (NGS)
title_full Current Progress in Investigating Mature T- and NK-Cell Lymphoma Gene Aberrations by Next-Generation Sequencing (NGS)
title_fullStr Current Progress in Investigating Mature T- and NK-Cell Lymphoma Gene Aberrations by Next-Generation Sequencing (NGS)
title_full_unstemmed Current Progress in Investigating Mature T- and NK-Cell Lymphoma Gene Aberrations by Next-Generation Sequencing (NGS)
title_short Current Progress in Investigating Mature T- and NK-Cell Lymphoma Gene Aberrations by Next-Generation Sequencing (NGS)
title_sort current progress in investigating mature t- and nk-cell lymphoma gene aberrations by next-generation sequencing (ngs)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259727/
https://www.ncbi.nlm.nih.gov/pubmed/34239326
http://dx.doi.org/10.2147/CMAR.S299505
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