Cargando…

Schizandrin A ameliorates cognitive functions via modulating microglial polarisation in Alzheimer’s disease mice

CONTEXT: Schizandrin A (Sch A) is a major phytochemical from Schisandra chinensis (Turcz.) Baill. (Schisandraceae), which exerts a neuroprotective effect in Alzheimer's disease (AD). OBJECTIVE: To investigate the mechanism of Sch A in AD. MATERIALS AND METHODS: AD group: APP/PS1 transgenic mice...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Qi, Liu, Li, Guan, Huibo, Zhou, Yanyan, Li, Quan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259827/ https://www.ncbi.nlm.nih.gov/pubmed/34214019 http://dx.doi.org/10.1080/13880209.2021.1941132

Ejemplares similares

Schizandrin, an Antioxidant Lignan from Schisandra chinensis, Ameliorates Aβ (1–42)-Induced Memory Impairment in Mice
por: Hu, Di, et al.
Publicado: (2012)

Schisandrin Inhibits NLRP1 Inflammasome-Mediated Neuronal Pyroptosis in Mouse Models of Alzheimer’s Disease
por: Li, Quan, et al.
Publicado: (2021)

Far infrared light irradiation enhances Aβ clearance via increased exocytotic microglial ATP and ameliorates cognitive deficit in Alzheimer’s disease-like mice
por: Li, Qingyong, et al.
Publicado: (2022)

Biomimetic Remodeling of Microglial Riboflavin Metabolism Ameliorates Cognitive Impairment by Modulating Neuroinflammation
por: Zhang, Mengran, et al.
Publicado: (2023)

Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model
por: Zhong, Li, et al.
Publicado: (2019)

Saponins from Panax japonicus attenuate cognitive impairment in ageing rats through regulating microglial polarisation and autophagy
por: Pi, Xue-Jiao, et al.
Publicado: (2021)

Schizandrin A exhibits potent anticancer activity in colorectal cancer cells by inhibiting heat shock factor 1
por: Chen, Bing-chen, et al.
Publicado: (2020)

Pharmacokinetics of Schizandrin and Its Pharmaceutical Products Assessed Using a Validated LC–MS/MS Method
por: Li, Chi-Lin, et al.
Publicado: (2018)

A metabonomic study of cardioprotection of ginsenosides, schizandrin, and ophiopogonin D against acute myocardial infarction in rats
por: Jiang, Miaomiao, et al.
Publicado: (2014)

Author Correction: Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model
por: Zhong, Li, et al.
Publicado: (2019)

Enrichment and Purification of Deoxyschizandrin and γ-Schizandrin from the Extract of Schisandra chinensis Fruit by Macroporous Resins
por: Yang, Feng-Jian, et al.
Publicado: (2012)

Nano-Honokiol ameliorates the cognitive deficits in TgCRND8 mice of Alzheimer’s disease via inhibiting neuropathology and modulating gut microbiota
por: Qu, Chang, et al.
Publicado: (2021)

Inhibition of microfold cells ameliorates early pathological phenotypes by modulating microglial functions in Alzheimer’s disease mouse model
por: Kim, Namkwon, et al.
Publicado: (2023)

Sodium rutin ameliorates Alzheimer’s disease–like pathology by enhancing microglial amyloid-β clearance
por: Pan, Rui-Yuan, et al.
Publicado: (2019)

A Novel Peroxidase Mimics and Ameliorates Alzheimer’s Disease-Related Pathology and Cognitive Decline in Mice
por: Xu, Jia, et al.
Publicado: (2018)

Schizandrin A exerts anti-tumor effects on A375 cells by down-regulating H19
por: Bi, Yiming, et al.
Publicado: (2019)

A Maitake (Grifola frondosa) polysaccharide ameliorates Alzheimer's disease-like pathology and cognitive impairments by enhancing microglial amyloid-β clearance
por: Bai, Yao, et al.
Publicado: (2019)

Mild endoplasmic reticulum stress ameliorates lipopolysaccharide-induced neuroinflammation and cognitive impairment via regulation of microglial polarization
por: Wang, Yi-wei, et al.
Publicado: (2017)

Schizandrin Protects against OGD/R-Induced Neuronal Injury by Suppressing Autophagy: Involvement of the AMPK/mTOR Pathway
por: Wang, Guangyun, et al.
Publicado: (2019)

Astrocytic and microglial cells as the modulators of neuroinflammation in Alzheimer’s disease
por: Singh, Deepali
Publicado: (2022)

2-carba cyclic phosphatidic acid suppresses inflammation via regulation of microglial polarisation in the stab-wounded mouse cerebral cortex
por: Hashimoto, Kei, et al.
Publicado: (2018)

Microglial autophagy in Alzheimer’s disease and Parkinson’s disease
por: Wang, Zhifu, et al.
Publicado: (2023)

Correction to: Mild endoplasmic reticulum stress ameliorates lipopolysaccharide-induced neuroinflammation and cognitive impairment via regulation of microglial polarization
por: Wang, Yi-wei, et al.
Publicado: (2020)

Microglial activation and tau burden predict cognitive decline in Alzheimer’s disease
por: Malpetti, Maura, et al.
Publicado: (2020)

Schizandrin B attenuates hypoxia/reoxygenation injury in H9c2 cells by activating the AMPK/Nrf2 signaling pathway
por: Zhao, Bo, et al.
Publicado: (2021)

Platycodigenin as Potential Drug Candidate for Alzheimer’s Disease via Modulating Microglial Polarization and Neurite Regeneration
por: Yang, Zhiyou, et al.
Publicado: (2019)

NLRP3-dependent microglial training impaired the clearance of amyloid-beta and aggravated the cognitive decline in Alzheimer’s disease
por: He, Xiao-fei, et al.
Publicado: (2020)

Schizandrin A induces the apoptosis and suppresses the proliferation, invasion and migration of gastric cancer cells by activating endoplasmic reticulum stress
por: Pu, Huachao, et al.
Publicado: (2021)

A microemulsion co-loaded with Schizandrin A–docetaxel enhances esophageal carcinoma treatment through overcoming multidrug resistance
por: Su, Xiangyu, et al.
Publicado: (2017)

Schizandrin C regulates lipid metabolism and inflammation in liver fibrosis by NF-κB and p38/ERK MAPK signaling pathways
por: Chen, Panpan, et al.
Publicado: (2023)

Akkermansia muciniphila supplementation prevents cognitive impairment in sleep-deprived mice by modulating microglial engulfment of synapses
por: Li, Na, et al.
Publicado: (2023)

Correction to: NLRP3-dependent microglial training impaired the clearance of amyloid-beta and aggravated the cognitive decline in Alzheimer’s disease
por: He, Xiao-fei, et al.
Publicado: (2022)

DSCR1 deficiency ameliorates the Aβ pathology of Alzheimer’s disease by enhancing microglial activity
por: Choi, Chiyeol, et al.
Publicado: (2022)

Commentary: Mild endoplasmic reticulum stress ameliorates lpopolysaccharide-induced neuroinflammation and cognitive impairment via regulation of microglial polarization
por: Rai, Sachchida N., et al.
Publicado: (2018)

Microglial FABP4-UCP2 Axis Modulates Neuroinflammation and Cognitive Decline in Obese Mice
por: So, Simon W., et al.
Publicado: (2022)

Long-term treatment with intranasal insulin ameliorates cognitive impairment, tau hyperphosphorylation, and microglial activation in a streptozotocin-induced Alzheimer’s rat model
por: Guo, Zhangyu, et al.
Publicado: (2017)

Phosphoinositides signaling modulates microglial actin remodeling and phagocytosis in Alzheimer’s disease
por: Desale, Smita Eknath, et al.
Publicado: (2021)

An intranasally delivered peptide drug ameliorates cognitive decline in Alzheimer transgenic mice
por: Cheng, Yu‐Sung, et al.
Publicado: (2017)

Pertussis Toxin Ameliorates Microglial Activation Associated With Ischemic Stroke
por: Zhou, Feihui, et al.
Publicado: (2020)

Schizandrin Protects Primary Rat Cortical Cell Cultures from Glutamate-Induced Apoptosis by Inhibiting Activation of the MAPK Family and the Mitochondria Dependent Pathway
por: Lee, Meng-Shiou, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_cdvb6rg3t9jkq734ds08b5sarq