Impact of natural selection on global patterns of genetic variation, and association with clinical phenotypes, at genes involved in SARS-CoV-2 infection

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We investigated global patterns of genetic variation and signatures of natural selection at host genes relevant to SARS-CoV-2 infection (ACE2, TMPRSS2, DPP4, and LY6E). We analyzed novel data from 2,012 ethnically diverse Africans and 15,997 individuals of European and African ancestry with electron...

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Detalles Bibliográficos
Autores principales: Zhang, Chao, Verma, Anurag, Feng, Yuanqing, Melo, Marcelo C. R., McQuillan, Michael, Hansen, Matthew, Lucas, Anastasia, Park, Joseph, Ranciaro, Alessia, Thompson, Simon, Rubel, Meghan A., Campbell, Michael C., Beggs, William, Hirbo, Jibril, Mpoloka, Sununguko Wata, Mokone, Gaonyadiwe George, Nyambo, Thomas, Meskel, Dawit Wolde, Belay, Gurja, Fokunang, Charles, Njamnshi, Alfred K., Omar, Sabah A., Williams, Scott M., Rader, Daniel, Ritchie, Marylyn D., de la Fuente Nunez, Cesar, Sirugo, Giorgio, Tishkoff, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259910/
https://www.ncbi.nlm.nih.gov/pubmed/34230933
http://dx.doi.org/10.1101/2021.06.28.21259529
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