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Heroin-Induced Acute Pancreatitis

Heroin-induced pancreatitis (HIP) is rare with only a few cases reported previously in the literature and the pathophysiology mechanism is yet to be investigated. We present two cases of acute pancreatitis (AP) in the setting of acute heroin (diacetylmorphine) intoxication. Both patients presented w...

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Autores principales: Ciobanu, Camelia, Jadav, Raja Shekar, Colon Ramos, Ana, Sequeira Gross, Harry G, Brazzarola, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260205/
https://www.ncbi.nlm.nih.gov/pubmed/34262808
http://dx.doi.org/10.7759/cureus.15470
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author Ciobanu, Camelia
Jadav, Raja Shekar
Colon Ramos, Ana
Sequeira Gross, Harry G
Brazzarola, Carlos
author_facet Ciobanu, Camelia
Jadav, Raja Shekar
Colon Ramos, Ana
Sequeira Gross, Harry G
Brazzarola, Carlos
author_sort Ciobanu, Camelia
collection PubMed
description Heroin-induced pancreatitis (HIP) is rare with only a few cases reported previously in the literature and the pathophysiology mechanism is yet to be investigated. We present two cases of acute pancreatitis (AP) in the setting of acute heroin (diacetylmorphine) intoxication. Both patients presented with nausea, vomiting and severe abdominal pain after intranasal heroin use. On laboratory analysis were found to have elevated serum lipase, positive urine toxicology for opioids, without any other obvious causes for AP. Both patients had a full recovery with supportive treatment. As a general approach, drug-induced pancreatitis is a diagnosis of exclusion and a high index of suspicion is required when the most common etiologies are ruled out.
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spelling pubmed-82602052021-07-13 Heroin-Induced Acute Pancreatitis Ciobanu, Camelia Jadav, Raja Shekar Colon Ramos, Ana Sequeira Gross, Harry G Brazzarola, Carlos Cureus Internal Medicine Heroin-induced pancreatitis (HIP) is rare with only a few cases reported previously in the literature and the pathophysiology mechanism is yet to be investigated. We present two cases of acute pancreatitis (AP) in the setting of acute heroin (diacetylmorphine) intoxication. Both patients presented with nausea, vomiting and severe abdominal pain after intranasal heroin use. On laboratory analysis were found to have elevated serum lipase, positive urine toxicology for opioids, without any other obvious causes for AP. Both patients had a full recovery with supportive treatment. As a general approach, drug-induced pancreatitis is a diagnosis of exclusion and a high index of suspicion is required when the most common etiologies are ruled out. Cureus 2021-06-05 /pmc/articles/PMC8260205/ /pubmed/34262808 http://dx.doi.org/10.7759/cureus.15470 Text en Copyright © 2021, Ciobanu et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Ciobanu, Camelia
Jadav, Raja Shekar
Colon Ramos, Ana
Sequeira Gross, Harry G
Brazzarola, Carlos
Heroin-Induced Acute Pancreatitis
title Heroin-Induced Acute Pancreatitis
title_full Heroin-Induced Acute Pancreatitis
title_fullStr Heroin-Induced Acute Pancreatitis
title_full_unstemmed Heroin-Induced Acute Pancreatitis
title_short Heroin-Induced Acute Pancreatitis
title_sort heroin-induced acute pancreatitis
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260205/
https://www.ncbi.nlm.nih.gov/pubmed/34262808
http://dx.doi.org/10.7759/cureus.15470
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