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Translation stress and collided ribosomes are co-activators of cGAS

The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway senses cytosolic DNA and induces interferon-stimulated genes (ISGs) to activate the innate immune system. Here, we report the unexpected discovery that cGAS also senses dysfunctional protein production. Purified ribosome...

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Detalles Bibliográficos
Autores principales:	Wan, Li, Juszkiewicz, Szymon, Blears, Daniel, Bajpe, Prashanth Kumar, Han, Zhong, Faull, Peter, Mitter, Richard, Stewart, Aengus, Snijders, Ambrosius P., Hegde, Ramanujan S., Svejstrup, Jesper Q.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260207/ https://www.ncbi.nlm.nih.gov/pubmed/34111399 http://dx.doi.org/10.1016/j.molcel.2021.05.018

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