Exosome component 1 cleaves single-stranded DNA and sensitizes human kidney renal clear cell carcinoma cells to poly(ADP-ribose) polymerase inhibitor

Targeting DNA repair pathway offers an important therapeutic strategy for Homo sapiens (human) cancers. However, the failure of DNA repair inhibitors to markedly benefit patients necessitates the development of new strategies. Here, we show that exosome component 1 (EXOSC1) promotes DNA damages and...

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Detalles Bibliográficos
Autores principales: Liu, Qiaoling, Xiao, Qi, Sun, Zhen, Wang, Bo, Wang, Lina, Wang, Na, Wang, Kai, Song, Chengli, Yang, Qingkai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260222/
https://www.ncbi.nlm.nih.gov/pubmed/34159897
http://dx.doi.org/10.7554/eLife.69454

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260222/
https://www.ncbi.nlm.nih.gov/pubmed/34159897
http://dx.doi.org/10.7554/eLife.69454

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