Inflammation drives alternative first exon usage to regulate immune genes including a novel iron-regulated isoform of Aim2

Determining the layers of gene regulation within the innate immune response is critical to our understanding of the cellular responses to infection and dysregulation in disease. We identified a conserved mechanism of gene regulation in human and mouse via changes in alternative first exon (AFE) usag...

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Detalles Bibliográficos
Autores principales: Robinson, Elektra K, Jagannatha, Pratibha, Covarrubias, Sergio, Cattle, Matthew, Smaliy, Valeriya, Safavi, Rojin, Shapleigh, Barbara, Abu-Shumays, Robin, Jain, Miten, Cloonan, Suzanne M, Akeson, Mark, Brooks, Angela N, Carpenter, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260223/
https://www.ncbi.nlm.nih.gov/pubmed/34047695
http://dx.doi.org/10.7554/eLife.69431

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