Castration delays epigenetic aging and feminizes DNA methylation at androgen-regulated loci

In mammals, females generally live longer than males. Nevertheless, the mechanisms underpinning sex-dependent longevity are currently unclear. Epigenetic clocks are powerful biological biomarkers capable of precisely estimating chronological age and identifying novel factors influencing the aging ra...

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Detalles Bibliográficos
Autores principales: Sugrue, Victoria J, Zoller, Joseph Alan, Narayan, Pritika, Lu, Ake T, Ortega-Recalde, Oscar J, Grant, Matthew J, Bawden, C Simon, Rudiger, Skye R, Haghani, Amin, Bond, Donna M, Hore, Reuben R, Garratt, Michael, Sears, Karen E, Wang, Nan, Yang, Xiangdong William, Snell, Russell G, Hore, Timothy A, Horvath, Steve
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260231/
https://www.ncbi.nlm.nih.gov/pubmed/34227937
http://dx.doi.org/10.7554/eLife.64932

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