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Peripheral Oxidation Markers in Down Syndrome Patients: The Better and the Worse

Oxidative stress plays an important role in Down syndrome (DS) pathology since the gene dose effect leads to abnormal levels of certain enzymes and metabolites. In this review, we focused on relatively easy-to-obtain, peripheral markers of oxidative stress and inflammation, in order to compare the l...

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Autores principales: Szwajgier, Dominik, Baranowska-Wójcik, Ewa, Grzelczyk, Joanna, Żukiewicz-Sobczak, Wioletta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260317/
https://www.ncbi.nlm.nih.gov/pubmed/34257747
http://dx.doi.org/10.1155/2021/5581139
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author Szwajgier, Dominik
Baranowska-Wójcik, Ewa
Grzelczyk, Joanna
Żukiewicz-Sobczak, Wioletta
author_facet Szwajgier, Dominik
Baranowska-Wójcik, Ewa
Grzelczyk, Joanna
Żukiewicz-Sobczak, Wioletta
author_sort Szwajgier, Dominik
collection PubMed
description Oxidative stress plays an important role in Down syndrome (DS) pathology since the gene dose effect leads to abnormal levels of certain enzymes and metabolites. In this review, we focused on relatively easy-to-obtain, peripheral markers of oxidative stress and inflammation, in order to compare the levels of these markers in DS patients and chromosomally healthy persons. Studies taking into account age- and sex-matched control groups were of particular interest in this context. We analyzed the factors that influence the levels of said markers in both groups (i.e., the usefulness of the markers), including the age of DS patients, occurrence of regular trisomy 21 or mosaicism, physical activity of patients, and the onset of Alzheimer's disease in DS. This paper was conceived as a handbook—to help for selecting suitable, easy-to-obtain markers for monitoring of the health status of DS patients (e.g., in nutritional studies and during dietary supplementation).
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spelling pubmed-82603172021-07-12 Peripheral Oxidation Markers in Down Syndrome Patients: The Better and the Worse Szwajgier, Dominik Baranowska-Wójcik, Ewa Grzelczyk, Joanna Żukiewicz-Sobczak, Wioletta Dis Markers Review Article Oxidative stress plays an important role in Down syndrome (DS) pathology since the gene dose effect leads to abnormal levels of certain enzymes and metabolites. In this review, we focused on relatively easy-to-obtain, peripheral markers of oxidative stress and inflammation, in order to compare the levels of these markers in DS patients and chromosomally healthy persons. Studies taking into account age- and sex-matched control groups were of particular interest in this context. We analyzed the factors that influence the levels of said markers in both groups (i.e., the usefulness of the markers), including the age of DS patients, occurrence of regular trisomy 21 or mosaicism, physical activity of patients, and the onset of Alzheimer's disease in DS. This paper was conceived as a handbook—to help for selecting suitable, easy-to-obtain markers for monitoring of the health status of DS patients (e.g., in nutritional studies and during dietary supplementation). Hindawi 2021-06-28 /pmc/articles/PMC8260317/ /pubmed/34257747 http://dx.doi.org/10.1155/2021/5581139 Text en Copyright © 2021 Dominik Szwajgier et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Szwajgier, Dominik
Baranowska-Wójcik, Ewa
Grzelczyk, Joanna
Żukiewicz-Sobczak, Wioletta
Peripheral Oxidation Markers in Down Syndrome Patients: The Better and the Worse
title Peripheral Oxidation Markers in Down Syndrome Patients: The Better and the Worse
title_full Peripheral Oxidation Markers in Down Syndrome Patients: The Better and the Worse
title_fullStr Peripheral Oxidation Markers in Down Syndrome Patients: The Better and the Worse
title_full_unstemmed Peripheral Oxidation Markers in Down Syndrome Patients: The Better and the Worse
title_short Peripheral Oxidation Markers in Down Syndrome Patients: The Better and the Worse
title_sort peripheral oxidation markers in down syndrome patients: the better and the worse
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260317/
https://www.ncbi.nlm.nih.gov/pubmed/34257747
http://dx.doi.org/10.1155/2021/5581139
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