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Peripheral Oxidation Markers in Down Syndrome Patients: The Better and the Worse
Oxidative stress plays an important role in Down syndrome (DS) pathology since the gene dose effect leads to abnormal levels of certain enzymes and metabolites. In this review, we focused on relatively easy-to-obtain, peripheral markers of oxidative stress and inflammation, in order to compare the l...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260317/ https://www.ncbi.nlm.nih.gov/pubmed/34257747 http://dx.doi.org/10.1155/2021/5581139 |
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author | Szwajgier, Dominik Baranowska-Wójcik, Ewa Grzelczyk, Joanna Żukiewicz-Sobczak, Wioletta |
author_facet | Szwajgier, Dominik Baranowska-Wójcik, Ewa Grzelczyk, Joanna Żukiewicz-Sobczak, Wioletta |
author_sort | Szwajgier, Dominik |
collection | PubMed |
description | Oxidative stress plays an important role in Down syndrome (DS) pathology since the gene dose effect leads to abnormal levels of certain enzymes and metabolites. In this review, we focused on relatively easy-to-obtain, peripheral markers of oxidative stress and inflammation, in order to compare the levels of these markers in DS patients and chromosomally healthy persons. Studies taking into account age- and sex-matched control groups were of particular interest in this context. We analyzed the factors that influence the levels of said markers in both groups (i.e., the usefulness of the markers), including the age of DS patients, occurrence of regular trisomy 21 or mosaicism, physical activity of patients, and the onset of Alzheimer's disease in DS. This paper was conceived as a handbook—to help for selecting suitable, easy-to-obtain markers for monitoring of the health status of DS patients (e.g., in nutritional studies and during dietary supplementation). |
format | Online Article Text |
id | pubmed-8260317 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-82603172021-07-12 Peripheral Oxidation Markers in Down Syndrome Patients: The Better and the Worse Szwajgier, Dominik Baranowska-Wójcik, Ewa Grzelczyk, Joanna Żukiewicz-Sobczak, Wioletta Dis Markers Review Article Oxidative stress plays an important role in Down syndrome (DS) pathology since the gene dose effect leads to abnormal levels of certain enzymes and metabolites. In this review, we focused on relatively easy-to-obtain, peripheral markers of oxidative stress and inflammation, in order to compare the levels of these markers in DS patients and chromosomally healthy persons. Studies taking into account age- and sex-matched control groups were of particular interest in this context. We analyzed the factors that influence the levels of said markers in both groups (i.e., the usefulness of the markers), including the age of DS patients, occurrence of regular trisomy 21 or mosaicism, physical activity of patients, and the onset of Alzheimer's disease in DS. This paper was conceived as a handbook—to help for selecting suitable, easy-to-obtain markers for monitoring of the health status of DS patients (e.g., in nutritional studies and during dietary supplementation). Hindawi 2021-06-28 /pmc/articles/PMC8260317/ /pubmed/34257747 http://dx.doi.org/10.1155/2021/5581139 Text en Copyright © 2021 Dominik Szwajgier et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Szwajgier, Dominik Baranowska-Wójcik, Ewa Grzelczyk, Joanna Żukiewicz-Sobczak, Wioletta Peripheral Oxidation Markers in Down Syndrome Patients: The Better and the Worse |
title | Peripheral Oxidation Markers in Down Syndrome Patients: The Better and the Worse |
title_full | Peripheral Oxidation Markers in Down Syndrome Patients: The Better and the Worse |
title_fullStr | Peripheral Oxidation Markers in Down Syndrome Patients: The Better and the Worse |
title_full_unstemmed | Peripheral Oxidation Markers in Down Syndrome Patients: The Better and the Worse |
title_short | Peripheral Oxidation Markers in Down Syndrome Patients: The Better and the Worse |
title_sort | peripheral oxidation markers in down syndrome patients: the better and the worse |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260317/ https://www.ncbi.nlm.nih.gov/pubmed/34257747 http://dx.doi.org/10.1155/2021/5581139 |
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