Cargando…
Cerebral blood flow velocity during simultaneous changes in mean arterial pressure and cardiac output in healthy volunteers
PURPOSE: Cerebral blood flow (CBF) needs to be precisely controlled to maintain brain functions. While previously believed to be autoregulated and near constant over a wide blood pressure range, CBF is now understood as more pressure passive. However, there are still questions regarding the integrat...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260418/ https://www.ncbi.nlm.nih.gov/pubmed/33890157 http://dx.doi.org/10.1007/s00421-021-04693-6 |
_version_ | 1783718809233784832 |
---|---|
author | Lie, Sole Lindvåg Hisdal, Jonny Høiseth, Lars Øivind |
author_facet | Lie, Sole Lindvåg Hisdal, Jonny Høiseth, Lars Øivind |
author_sort | Lie, Sole Lindvåg |
collection | PubMed |
description | PURPOSE: Cerebral blood flow (CBF) needs to be precisely controlled to maintain brain functions. While previously believed to be autoregulated and near constant over a wide blood pressure range, CBF is now understood as more pressure passive. However, there are still questions regarding the integrated nature of CBF regulation and more specifically the role of cardiac output. Our aim was, therefore, to explore the effects of MAP and cardiac output on CBF in a combined model of reduced preload and increased afterload. METHOD: 16 healthy volunteers were exposed to combinations of different levels of simultaneous lower body negative pressure and isometric hand grip. We measured blood velocity in the middle cerebral artery (MCAV) and internal carotid artery (ICAV) by Doppler ultrasound, and cerebral oxygen saturation (ScO(2)) by near-infrared spectroscopy, as surrogates for CBF. The effect of changes in MAP and cardiac output on CBF was estimated with mixed multiple regression. RESULT: Both MAP and cardiac output had independent effects on MCAV, ICAV and ScO(2). For ICAV and ScO(2) there was also a statistically significant interaction effect between MAP and cardiac output. The estimated effect of a change of 10 mmHg in MAP on MCAV was 3.11 cm/s (95% CI 2.51–3.71, P < 0.001), and the effect of a change of 1 L/min in cardiac output was 3.41 cm/s (95% CI 2.82–4.00, P < 0.001). CONCLUSION: The present study indicates that during reductions in cardiac output, both MAP and cardiac output have independent effects on CBF. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00421-021-04693-6. |
format | Online Article Text |
id | pubmed-8260418 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-82604182021-07-20 Cerebral blood flow velocity during simultaneous changes in mean arterial pressure and cardiac output in healthy volunteers Lie, Sole Lindvåg Hisdal, Jonny Høiseth, Lars Øivind Eur J Appl Physiol Original Article PURPOSE: Cerebral blood flow (CBF) needs to be precisely controlled to maintain brain functions. While previously believed to be autoregulated and near constant over a wide blood pressure range, CBF is now understood as more pressure passive. However, there are still questions regarding the integrated nature of CBF regulation and more specifically the role of cardiac output. Our aim was, therefore, to explore the effects of MAP and cardiac output on CBF in a combined model of reduced preload and increased afterload. METHOD: 16 healthy volunteers were exposed to combinations of different levels of simultaneous lower body negative pressure and isometric hand grip. We measured blood velocity in the middle cerebral artery (MCAV) and internal carotid artery (ICAV) by Doppler ultrasound, and cerebral oxygen saturation (ScO(2)) by near-infrared spectroscopy, as surrogates for CBF. The effect of changes in MAP and cardiac output on CBF was estimated with mixed multiple regression. RESULT: Both MAP and cardiac output had independent effects on MCAV, ICAV and ScO(2). For ICAV and ScO(2) there was also a statistically significant interaction effect between MAP and cardiac output. The estimated effect of a change of 10 mmHg in MAP on MCAV was 3.11 cm/s (95% CI 2.51–3.71, P < 0.001), and the effect of a change of 1 L/min in cardiac output was 3.41 cm/s (95% CI 2.82–4.00, P < 0.001). CONCLUSION: The present study indicates that during reductions in cardiac output, both MAP and cardiac output have independent effects on CBF. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00421-021-04693-6. Springer Berlin Heidelberg 2021-04-22 2021 /pmc/articles/PMC8260418/ /pubmed/33890157 http://dx.doi.org/10.1007/s00421-021-04693-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Lie, Sole Lindvåg Hisdal, Jonny Høiseth, Lars Øivind Cerebral blood flow velocity during simultaneous changes in mean arterial pressure and cardiac output in healthy volunteers |
title | Cerebral blood flow velocity during simultaneous changes in mean arterial pressure and cardiac output in healthy volunteers |
title_full | Cerebral blood flow velocity during simultaneous changes in mean arterial pressure and cardiac output in healthy volunteers |
title_fullStr | Cerebral blood flow velocity during simultaneous changes in mean arterial pressure and cardiac output in healthy volunteers |
title_full_unstemmed | Cerebral blood flow velocity during simultaneous changes in mean arterial pressure and cardiac output in healthy volunteers |
title_short | Cerebral blood flow velocity during simultaneous changes in mean arterial pressure and cardiac output in healthy volunteers |
title_sort | cerebral blood flow velocity during simultaneous changes in mean arterial pressure and cardiac output in healthy volunteers |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260418/ https://www.ncbi.nlm.nih.gov/pubmed/33890157 http://dx.doi.org/10.1007/s00421-021-04693-6 |
work_keys_str_mv | AT liesolelindvag cerebralbloodflowvelocityduringsimultaneouschangesinmeanarterialpressureandcardiacoutputinhealthyvolunteers AT hisdaljonny cerebralbloodflowvelocityduringsimultaneouschangesinmeanarterialpressureandcardiacoutputinhealthyvolunteers AT høisethlarsøivind cerebralbloodflowvelocityduringsimultaneouschangesinmeanarterialpressureandcardiacoutputinhealthyvolunteers |