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TiO(2) supported single Ag atoms nanozyme for elimination of SARS-CoV2
The outbreak of SARS-coronavirus 2 (SARS-CoV2) has become a global health emergency. Although enormous efforts have been made, there is still no effective treatment against the new virus. Herein, a TiO(2) supported single-atom nanozyme containing atomically dispersed Ag atoms (Ag-TiO(2) SAN) is desi...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Authors. Published by Elsevier Ltd.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260506/ https://www.ncbi.nlm.nih.gov/pubmed/34249143 http://dx.doi.org/10.1016/j.nantod.2021.101243 |
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author | Wang, Daji Zhang, Bin Ding, Hui Liu, Dan Xiang, Jianquan Gao, Xuejiao J. Chen, Xuehui Li, Zhongjun Yang, Lei Duan, Hongxia Zheng, Jiyan Liu, Zheng Jiang, Bing Liu, Yang Xie, Ni Zhang, Han Yan, Xiyun Fan, Kelong Nie, Guohui |
author_facet | Wang, Daji Zhang, Bin Ding, Hui Liu, Dan Xiang, Jianquan Gao, Xuejiao J. Chen, Xuehui Li, Zhongjun Yang, Lei Duan, Hongxia Zheng, Jiyan Liu, Zheng Jiang, Bing Liu, Yang Xie, Ni Zhang, Han Yan, Xiyun Fan, Kelong Nie, Guohui |
author_sort | Wang, Daji |
collection | PubMed |
description | The outbreak of SARS-coronavirus 2 (SARS-CoV2) has become a global health emergency. Although enormous efforts have been made, there is still no effective treatment against the new virus. Herein, a TiO(2) supported single-atom nanozyme containing atomically dispersed Ag atoms (Ag-TiO(2) SAN) is designed to serve as a highly efficient antiviral nanomaterial. Compared with traditional nano-TiO(2) and Ag, Ag-TiO(2) SAN exhibits higher adsorption (99.65%) of SARS-CoV2 pseudovirus. This adsorption ability is due to the interaction between SAN and receptor binding domain (RBD) of spike 1 protein of SARS-CoV2. Theoretical calculation and experimental evidences indicate that the Ag atoms of SAN strongly bind to cysteine and asparagine, which are the most abundant amino acids on the surface of spike 1 RBD. After binding to the virus, the SAN/virus complex is typically phagocytosed by macrophages and colocalized with lysosomes. Interestingly, Ag-TiO(2) SAN possesses high peroxidase-like activity responsible for reactive oxygen species production under acid conditions. The highly acidic microenvironment of lysosomes could favor oxygen reduction reaction process to eliminate the virus. With hACE2 transgenic mice, Ag-TiO(2) SAN showed efficient anti-SARS-CoV2 pseudovirus activity. In conclusion, Ag-TiO(2) SAN is a promising nanomaterial to achieve effective antiviral effects for SARS-CoV2. |
format | Online Article Text |
id | pubmed-8260506 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Authors. Published by Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82605062021-07-07 TiO(2) supported single Ag atoms nanozyme for elimination of SARS-CoV2 Wang, Daji Zhang, Bin Ding, Hui Liu, Dan Xiang, Jianquan Gao, Xuejiao J. Chen, Xuehui Li, Zhongjun Yang, Lei Duan, Hongxia Zheng, Jiyan Liu, Zheng Jiang, Bing Liu, Yang Xie, Ni Zhang, Han Yan, Xiyun Fan, Kelong Nie, Guohui Nano Today Article The outbreak of SARS-coronavirus 2 (SARS-CoV2) has become a global health emergency. Although enormous efforts have been made, there is still no effective treatment against the new virus. Herein, a TiO(2) supported single-atom nanozyme containing atomically dispersed Ag atoms (Ag-TiO(2) SAN) is designed to serve as a highly efficient antiviral nanomaterial. Compared with traditional nano-TiO(2) and Ag, Ag-TiO(2) SAN exhibits higher adsorption (99.65%) of SARS-CoV2 pseudovirus. This adsorption ability is due to the interaction between SAN and receptor binding domain (RBD) of spike 1 protein of SARS-CoV2. Theoretical calculation and experimental evidences indicate that the Ag atoms of SAN strongly bind to cysteine and asparagine, which are the most abundant amino acids on the surface of spike 1 RBD. After binding to the virus, the SAN/virus complex is typically phagocytosed by macrophages and colocalized with lysosomes. Interestingly, Ag-TiO(2) SAN possesses high peroxidase-like activity responsible for reactive oxygen species production under acid conditions. The highly acidic microenvironment of lysosomes could favor oxygen reduction reaction process to eliminate the virus. With hACE2 transgenic mice, Ag-TiO(2) SAN showed efficient anti-SARS-CoV2 pseudovirus activity. In conclusion, Ag-TiO(2) SAN is a promising nanomaterial to achieve effective antiviral effects for SARS-CoV2. The Authors. Published by Elsevier Ltd. 2021-10 2021-07-07 /pmc/articles/PMC8260506/ /pubmed/34249143 http://dx.doi.org/10.1016/j.nantod.2021.101243 Text en © 2021 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Wang, Daji Zhang, Bin Ding, Hui Liu, Dan Xiang, Jianquan Gao, Xuejiao J. Chen, Xuehui Li, Zhongjun Yang, Lei Duan, Hongxia Zheng, Jiyan Liu, Zheng Jiang, Bing Liu, Yang Xie, Ni Zhang, Han Yan, Xiyun Fan, Kelong Nie, Guohui TiO(2) supported single Ag atoms nanozyme for elimination of SARS-CoV2 |
title | TiO(2) supported single Ag atoms nanozyme for elimination of SARS-CoV2 |
title_full | TiO(2) supported single Ag atoms nanozyme for elimination of SARS-CoV2 |
title_fullStr | TiO(2) supported single Ag atoms nanozyme for elimination of SARS-CoV2 |
title_full_unstemmed | TiO(2) supported single Ag atoms nanozyme for elimination of SARS-CoV2 |
title_short | TiO(2) supported single Ag atoms nanozyme for elimination of SARS-CoV2 |
title_sort | tio(2) supported single ag atoms nanozyme for elimination of sars-cov2 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260506/ https://www.ncbi.nlm.nih.gov/pubmed/34249143 http://dx.doi.org/10.1016/j.nantod.2021.101243 |
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