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Elevated resting heart rate as a predictor of inflammation and cardiovascular risk in healthy obese individuals

The role of leukocyte inflammatory markers and toll like receptors (TLRs)2/4 in pathologies associated with elevated resting heart rate (RHR) levels in healthy obese (HO) individuals is not well elucidated. Herein, we investigated the relationship of RHR with expression of leukocyte-inflammatory mar...

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Autores principales: Al-Rashed, Fatema, Sindhu, Sardar, Al Madhoun, Ashraf, Ahmad, Zunair, AlMekhled, Dawood, Azim, Rafaat, Al-Kandari, Sarah, Wahid, Maziad Al-Abdul, Al-Mulla, Fahd, Ahmad, Rasheed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260607/
https://www.ncbi.nlm.nih.gov/pubmed/34230580
http://dx.doi.org/10.1038/s41598-021-93449-5
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author Al-Rashed, Fatema
Sindhu, Sardar
Al Madhoun, Ashraf
Ahmad, Zunair
AlMekhled, Dawood
Azim, Rafaat
Al-Kandari, Sarah
Wahid, Maziad Al-Abdul
Al-Mulla, Fahd
Ahmad, Rasheed
author_facet Al-Rashed, Fatema
Sindhu, Sardar
Al Madhoun, Ashraf
Ahmad, Zunair
AlMekhled, Dawood
Azim, Rafaat
Al-Kandari, Sarah
Wahid, Maziad Al-Abdul
Al-Mulla, Fahd
Ahmad, Rasheed
author_sort Al-Rashed, Fatema
collection PubMed
description The role of leukocyte inflammatory markers and toll like receptors (TLRs)2/4 in pathologies associated with elevated resting heart rate (RHR) levels in healthy obese (HO) individuals is not well elucidated. Herein, we investigated the relationship of RHR with expression of leukocyte-inflammatory markers and TLRs in HO individuals. 58-obese and 57-lean participants with no history of a major medical condition, were recruited in this study. In HO individuals, the elevated-RHR correlated positively with diastolic blood pressure, cholesterol, pro-inflammatory monocytes CD11b(+)CD11c(+)CD206(−) phenotype (r = 0.52, P = 0.0003) as well as with activated T cells CD8(+)HLA-DR(+) phenotype (r = 0.27, P = 0.039). No association was found between RHR and the percentage of CD16(+)CD11b(+) neutrophils. Interestingly, elevated RHR positively correlated with cells expressing TLR4 and TLR2 (CD14(+)TLR4(+), r = 0.51, P ≤ 0.0001; and CD14(+)TLR2(+), r = 0.42, P = 0.001). TLR4(+) expressing cells also associated positively with the plasma concentrations of proinflammatory or vascular permeability/matrix modulatory markers including TNF-α (r = 0.36, P = 0.005), VEGF (r = 0.47, P = 0.0002), and MMP-9 (r = 0.53, P ≤ 0.0001). Multiple regression revealed that RHR is independently associated with CD14(+)TLR4(+) monocytes and VEGF. We conclude that in HO individuals, increased CD14(+)TLR4(+) monocytes and circulatory VEGF levels associated independently with RHR, implying that RHR monitoring could be used as a non-invasive clinical indicator to identify healthy obese individuals at an increased risk of developing inflammation and cardiovascular disease.
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spelling pubmed-82606072021-07-08 Elevated resting heart rate as a predictor of inflammation and cardiovascular risk in healthy obese individuals Al-Rashed, Fatema Sindhu, Sardar Al Madhoun, Ashraf Ahmad, Zunair AlMekhled, Dawood Azim, Rafaat Al-Kandari, Sarah Wahid, Maziad Al-Abdul Al-Mulla, Fahd Ahmad, Rasheed Sci Rep Article The role of leukocyte inflammatory markers and toll like receptors (TLRs)2/4 in pathologies associated with elevated resting heart rate (RHR) levels in healthy obese (HO) individuals is not well elucidated. Herein, we investigated the relationship of RHR with expression of leukocyte-inflammatory markers and TLRs in HO individuals. 58-obese and 57-lean participants with no history of a major medical condition, were recruited in this study. In HO individuals, the elevated-RHR correlated positively with diastolic blood pressure, cholesterol, pro-inflammatory monocytes CD11b(+)CD11c(+)CD206(−) phenotype (r = 0.52, P = 0.0003) as well as with activated T cells CD8(+)HLA-DR(+) phenotype (r = 0.27, P = 0.039). No association was found between RHR and the percentage of CD16(+)CD11b(+) neutrophils. Interestingly, elevated RHR positively correlated with cells expressing TLR4 and TLR2 (CD14(+)TLR4(+), r = 0.51, P ≤ 0.0001; and CD14(+)TLR2(+), r = 0.42, P = 0.001). TLR4(+) expressing cells also associated positively with the plasma concentrations of proinflammatory or vascular permeability/matrix modulatory markers including TNF-α (r = 0.36, P = 0.005), VEGF (r = 0.47, P = 0.0002), and MMP-9 (r = 0.53, P ≤ 0.0001). Multiple regression revealed that RHR is independently associated with CD14(+)TLR4(+) monocytes and VEGF. We conclude that in HO individuals, increased CD14(+)TLR4(+) monocytes and circulatory VEGF levels associated independently with RHR, implying that RHR monitoring could be used as a non-invasive clinical indicator to identify healthy obese individuals at an increased risk of developing inflammation and cardiovascular disease. Nature Publishing Group UK 2021-07-06 /pmc/articles/PMC8260607/ /pubmed/34230580 http://dx.doi.org/10.1038/s41598-021-93449-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Al-Rashed, Fatema
Sindhu, Sardar
Al Madhoun, Ashraf
Ahmad, Zunair
AlMekhled, Dawood
Azim, Rafaat
Al-Kandari, Sarah
Wahid, Maziad Al-Abdul
Al-Mulla, Fahd
Ahmad, Rasheed
Elevated resting heart rate as a predictor of inflammation and cardiovascular risk in healthy obese individuals
title Elevated resting heart rate as a predictor of inflammation and cardiovascular risk in healthy obese individuals
title_full Elevated resting heart rate as a predictor of inflammation and cardiovascular risk in healthy obese individuals
title_fullStr Elevated resting heart rate as a predictor of inflammation and cardiovascular risk in healthy obese individuals
title_full_unstemmed Elevated resting heart rate as a predictor of inflammation and cardiovascular risk in healthy obese individuals
title_short Elevated resting heart rate as a predictor of inflammation and cardiovascular risk in healthy obese individuals
title_sort elevated resting heart rate as a predictor of inflammation and cardiovascular risk in healthy obese individuals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260607/
https://www.ncbi.nlm.nih.gov/pubmed/34230580
http://dx.doi.org/10.1038/s41598-021-93449-5
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