High-throughput 5′ UTR engineering for enhanced protein production in non-viral gene therapies

Despite significant clinical progress in cell and gene therapies, maximizing protein expression in order to enhance potency remains a major technical challenge. Here, we develop a high-throughput strategy to design, screen, and optimize 5′ UTRs that enhance protein expression from a strong human cyt...

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Detalles Bibliográficos
Autores principales: Cao, Jicong, Novoa, Eva Maria, Zhang, Zhizhuo, Chen, William C. W., Liu, Dianbo, Choi, Gigi C. G., Wong, Alan S. L., Wehrspaun, Claudia, Kellis, Manolis, Lu, Timothy K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260622/
https://www.ncbi.nlm.nih.gov/pubmed/34230498
http://dx.doi.org/10.1038/s41467-021-24436-7

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