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Septin4 promotes cardiomyocytes apoptosis by enhancing the VHL-mediated degradation of HIF-1α
Septin4, a protein localized at mitochondrion, can promote cells apoptosis mainly by binding XIAP (X-linked inhibitors of apoptosis), however, nothing is known about the role and mechanism of Septin4 in cardiomyocytes apoptosis. Here in the current study, we report that HIF-1α (hypoxia-inducible fac...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260662/ https://www.ncbi.nlm.nih.gov/pubmed/34230460 http://dx.doi.org/10.1038/s41420-021-00563-4 |