Case Report: Adult Post-COVID-19 Multisystem Inflammatory Syndrome and Thrombotic Microangiopathy

BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has affected millions of people worldwide. A clinical series of Kawasaki-like multisystem inflammatory syndrome (MIS), occurring after SARS-CoV-2 infection, have been described in children (MIS-C) and adults (MIS-A), but the pathophysiolog...

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Autores principales: Boudhabhay, Idris, Rabant, Marion, Roumenina, Lubka T., Coupry, Louis-Marie, Poillerat, Victoria, Marchal, Armance, Frémeaux-Bacchi, Véronique, El Karoui, Khalil, Monchi, Mehran, Pourcine, Franck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260674/
https://www.ncbi.nlm.nih.gov/pubmed/34248962
http://dx.doi.org/10.3389/fimmu.2021.680567
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author Boudhabhay, Idris
Rabant, Marion
Roumenina, Lubka T.
Coupry, Louis-Marie
Poillerat, Victoria
Marchal, Armance
Frémeaux-Bacchi, Véronique
El Karoui, Khalil
Monchi, Mehran
Pourcine, Franck
author_facet Boudhabhay, Idris
Rabant, Marion
Roumenina, Lubka T.
Coupry, Louis-Marie
Poillerat, Victoria
Marchal, Armance
Frémeaux-Bacchi, Véronique
El Karoui, Khalil
Monchi, Mehran
Pourcine, Franck
author_sort Boudhabhay, Idris
collection PubMed
description BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has affected millions of people worldwide. A clinical series of Kawasaki-like multisystem inflammatory syndrome (MIS), occurring after SARS-CoV-2 infection, have been described in children (MIS-C) and adults (MIS-A), but the pathophysiology remains unknown. CASE PRESENTATION: We describe a case of post-COVID-19 MIS-A in a 46-year-old man with biopsy-proven renal thrombotic microangiopathy (TMA). Specific complement inhibition with eculizumab was initiated promptly and led to a dramatic improvement of renal function. CONCLUSION: Our case suggests that that TMA could play a central role in the pathophysiology of post-COVID-19 MIS-A, making complement blockers an interesting therapeutic option.
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spelling pubmed-82606742021-07-08 Case Report: Adult Post-COVID-19 Multisystem Inflammatory Syndrome and Thrombotic Microangiopathy Boudhabhay, Idris Rabant, Marion Roumenina, Lubka T. Coupry, Louis-Marie Poillerat, Victoria Marchal, Armance Frémeaux-Bacchi, Véronique El Karoui, Khalil Monchi, Mehran Pourcine, Franck Front Immunol Immunology BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has affected millions of people worldwide. A clinical series of Kawasaki-like multisystem inflammatory syndrome (MIS), occurring after SARS-CoV-2 infection, have been described in children (MIS-C) and adults (MIS-A), but the pathophysiology remains unknown. CASE PRESENTATION: We describe a case of post-COVID-19 MIS-A in a 46-year-old man with biopsy-proven renal thrombotic microangiopathy (TMA). Specific complement inhibition with eculizumab was initiated promptly and led to a dramatic improvement of renal function. CONCLUSION: Our case suggests that that TMA could play a central role in the pathophysiology of post-COVID-19 MIS-A, making complement blockers an interesting therapeutic option. Frontiers Media S.A. 2021-06-23 /pmc/articles/PMC8260674/ /pubmed/34248962 http://dx.doi.org/10.3389/fimmu.2021.680567 Text en Copyright © 2021 Boudhabhay, Rabant, Roumenina, Coupry, Poillerat, Marchal, Frémeaux-Bacchi, El Karoui, Monchi and Pourcine https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Boudhabhay, Idris
Rabant, Marion
Roumenina, Lubka T.
Coupry, Louis-Marie
Poillerat, Victoria
Marchal, Armance
Frémeaux-Bacchi, Véronique
El Karoui, Khalil
Monchi, Mehran
Pourcine, Franck
Case Report: Adult Post-COVID-19 Multisystem Inflammatory Syndrome and Thrombotic Microangiopathy
title Case Report: Adult Post-COVID-19 Multisystem Inflammatory Syndrome and Thrombotic Microangiopathy
title_full Case Report: Adult Post-COVID-19 Multisystem Inflammatory Syndrome and Thrombotic Microangiopathy
title_fullStr Case Report: Adult Post-COVID-19 Multisystem Inflammatory Syndrome and Thrombotic Microangiopathy
title_full_unstemmed Case Report: Adult Post-COVID-19 Multisystem Inflammatory Syndrome and Thrombotic Microangiopathy
title_short Case Report: Adult Post-COVID-19 Multisystem Inflammatory Syndrome and Thrombotic Microangiopathy
title_sort case report: adult post-covid-19 multisystem inflammatory syndrome and thrombotic microangiopathy
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260674/
https://www.ncbi.nlm.nih.gov/pubmed/34248962
http://dx.doi.org/10.3389/fimmu.2021.680567
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