Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia

Spi-1 Proto-Oncogene (SPI1) fusion genes are recurrently found in T-cell acute lymphoblastic leukemia (T-ALL) cases but are insufficient to drive leukemogenesis. Here we show that SPI1 fusions in combination with activating NRAS mutations drive an immature T-ALL in vivo using a conditional bone marr...

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Detalles Bibliográficos
Autores principales: Van Thillo, Quentin, De Bie, Jolien, Seneviratne, Janith A., Demeyer, Sofie, Omari, Sofia, Balachandran, Anushree, Zhai, Vicki, Tam, Wai L., Sweron, Bram, Geerdens, Ellen, Gielen, Olga, Provost, Sarah, Segers, Heidi, Boeckx, Nancy, Marshall, Glenn M., Cheung, Belamy B., Isobe, Kiyotaka, Kato, Itaru, Takita, Junko, Amos, Timothy G., Deveson, Ira W., McCalmont, Hannah, Lock, Richard B., Oxley, Ethan P., Garwood, Maximilian M., Dickins, Ross A., Uyttebroeck, Anne, Carter, Daniel R., Cools, Jan, de Bock, Charles E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260768/
https://www.ncbi.nlm.nih.gov/pubmed/34230493
http://dx.doi.org/10.1038/s41467-021-24442-9

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