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Ramp-to-threshold dynamics in a hindbrain population controls the timing of spontaneous saccades

Organisms have the capacity to make decisions based solely on internal drives. However, it is unclear how neural circuits form decisions in the absence of sensory stimuli. Here we provide a comprehensive map of the activity patterns underlying the generation of saccades made in the absence of visual...

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Autores principales: Ramirez, Alexandro D., Aksay, Emre R. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260785/
https://www.ncbi.nlm.nih.gov/pubmed/34230474
http://dx.doi.org/10.1038/s41467-021-24336-w
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author Ramirez, Alexandro D.
Aksay, Emre R. F.
author_facet Ramirez, Alexandro D.
Aksay, Emre R. F.
author_sort Ramirez, Alexandro D.
collection PubMed
description Organisms have the capacity to make decisions based solely on internal drives. However, it is unclear how neural circuits form decisions in the absence of sensory stimuli. Here we provide a comprehensive map of the activity patterns underlying the generation of saccades made in the absence of visual stimuli. We perform calcium imaging in the larval zebrafish to discover a range of responses surrounding spontaneous saccades, from cells that display tonic discharge only during fixations to neurons whose activity rises in advance of saccades by multiple seconds. When we lesion cells in these populations we find that ablation of neurons with pre-saccadic rise delays saccade initiation. We analyze spontaneous saccade initiation using a ramp-to-threshold model and are able to predict the times of upcoming saccades using pre-saccadic activity. These findings suggest that ramping of neuronal activity to a bound is a critical component of self-initiated saccadic movements.
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spelling pubmed-82607852021-07-23 Ramp-to-threshold dynamics in a hindbrain population controls the timing of spontaneous saccades Ramirez, Alexandro D. Aksay, Emre R. F. Nat Commun Article Organisms have the capacity to make decisions based solely on internal drives. However, it is unclear how neural circuits form decisions in the absence of sensory stimuli. Here we provide a comprehensive map of the activity patterns underlying the generation of saccades made in the absence of visual stimuli. We perform calcium imaging in the larval zebrafish to discover a range of responses surrounding spontaneous saccades, from cells that display tonic discharge only during fixations to neurons whose activity rises in advance of saccades by multiple seconds. When we lesion cells in these populations we find that ablation of neurons with pre-saccadic rise delays saccade initiation. We analyze spontaneous saccade initiation using a ramp-to-threshold model and are able to predict the times of upcoming saccades using pre-saccadic activity. These findings suggest that ramping of neuronal activity to a bound is a critical component of self-initiated saccadic movements. Nature Publishing Group UK 2021-07-06 /pmc/articles/PMC8260785/ /pubmed/34230474 http://dx.doi.org/10.1038/s41467-021-24336-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Ramirez, Alexandro D.
Aksay, Emre R. F.
Ramp-to-threshold dynamics in a hindbrain population controls the timing of spontaneous saccades
title Ramp-to-threshold dynamics in a hindbrain population controls the timing of spontaneous saccades
title_full Ramp-to-threshold dynamics in a hindbrain population controls the timing of spontaneous saccades
title_fullStr Ramp-to-threshold dynamics in a hindbrain population controls the timing of spontaneous saccades
title_full_unstemmed Ramp-to-threshold dynamics in a hindbrain population controls the timing of spontaneous saccades
title_short Ramp-to-threshold dynamics in a hindbrain population controls the timing of spontaneous saccades
title_sort ramp-to-threshold dynamics in a hindbrain population controls the timing of spontaneous saccades
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260785/
https://www.ncbi.nlm.nih.gov/pubmed/34230474
http://dx.doi.org/10.1038/s41467-021-24336-w
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