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Joint disease-specificity at the regulatory base-pair level

Given the pleiotropic nature of coding sequences and that many loci exhibit multiple disease associations, it is within non-coding sequence that disease-specificity likely exists. Here, we focus on joint disorders, finding among replicated loci, that GDF5 exhibits over twenty distinct associations,...

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Detalles Bibliográficos
Autores principales:	Muthuirulan, Pushpanathan, Zhao, Dewei, Young, Mariel, Richard, Daniel, Liu, Zun, Emami, Alireza, Portilla, Gabriela, Hosseinzadeh, Shayan, Cao, Jiaxue, Maridas, David, Sedlak, Mary, Menghini, Danilo, Cheng, Liangliang, Li, Lu, Ding, Xinjia, Ding, Yan, Rosen, Vicki, Kiapour, Ata M., Capellini, Terence D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260791/ https://www.ncbi.nlm.nih.gov/pubmed/34230488 http://dx.doi.org/10.1038/s41467-021-24345-9

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