A cancer mutation promotes EphA4 oligomerization and signaling by altering the conformation of the SAM domain

The Eph receptor tyrosine kinases and their ephrin ligands regulate many physiological and pathological processes. EphA4 plays important roles in nervous system development and adult homeostasis, while aberrant EphA4 signaling has been implicated in neurodegeneration. EphA4 may also affect cancer ma...

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Detalles Bibliográficos
Autores principales: Light, Taylor P., Gomez-Soler, Maricel, Wang, Zichen, Karl, Kelly, Zapata-Mercado, Elmer, Gehring, Marina P., Lechtenberg, Bernhard C., Pogorelov, Taras V., Hristova, Kalina, Pasquale, Elena B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260879/
https://www.ncbi.nlm.nih.gov/pubmed/34139238
http://dx.doi.org/10.1016/j.jbc.2021.100876

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