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Stress Granules and Neurodegenerative Disorders: A Scoping Review
Cytoplasmic ribonucleoproteins called stress granules (SGs) are considered as one of the main cellular solutions against stress. Their temporary presence ends with stress relief. Any factor such as chronic stress or mutations in the structure of the components of SGs that lead to their permanent pre...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261063/ https://www.ncbi.nlm.nih.gov/pubmed/34248597 http://dx.doi.org/10.3389/fnagi.2021.650740 |
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author | Asadi, Mohammad Reza Sadat Moslehian, Marziyeh Sabaie, Hani Jalaiei, Abbas Ghafouri-Fard, Soudeh Taheri, Mohammad Rezazadeh, Maryam |
author_facet | Asadi, Mohammad Reza Sadat Moslehian, Marziyeh Sabaie, Hani Jalaiei, Abbas Ghafouri-Fard, Soudeh Taheri, Mohammad Rezazadeh, Maryam |
author_sort | Asadi, Mohammad Reza |
collection | PubMed |
description | Cytoplasmic ribonucleoproteins called stress granules (SGs) are considered as one of the main cellular solutions against stress. Their temporary presence ends with stress relief. Any factor such as chronic stress or mutations in the structure of the components of SGs that lead to their permanent presence can affect their interactions with pathological aggregations and increase the degenerative effects. SGs involved in RNA mechanisms are important factors in the pathophysiology of neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS), frontotemporal degeneration (FTD), and Alzheimer's diseases (AD). Although many studies have been performed in the field of SGs and neurodegenerative disorders, so far, no systematic studies have been executed in this field. The purpose of this study is to provide a comprehensive perspective of all studies about the role of SGs in the pathogenesis of neurodegenerative disorders with a focus on the protein ingredients of these granules. This scoping review is based on a six-stage methodology structure and the PRISMA guideline. A systematic search of seven databases for qualified articles was conducted until December 2020. Publications were screened independently by two reviewers and quantitative and qualitative analysis was performed on the extracted data. Bioinformatics analysis was used to plot the network and predict interprotein interactions. In addition, GO analysis was performed. A total of 48 articles were identified that comply the inclusion criteria. Most studies on neurodegenerative diseases have been conducted on ALS, AD, and FTD using human post mortem tissues. Human derived cell line studies have been used only in ALS. A total 29 genes of protein components of SGs have been studied, the most important of which are TDP-43, TIA-1, PABP-1. Bioinformatics studies have predicted 15 proteins to interact with the protein components of SGs, which may be the constituents of SGs. Understanding the interactions between SGs and pathological aggregations in neurodegenerative diseases can provide new targets for treatment of these disorders. |
format | Online Article Text |
id | pubmed-8261063 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82610632021-07-08 Stress Granules and Neurodegenerative Disorders: A Scoping Review Asadi, Mohammad Reza Sadat Moslehian, Marziyeh Sabaie, Hani Jalaiei, Abbas Ghafouri-Fard, Soudeh Taheri, Mohammad Rezazadeh, Maryam Front Aging Neurosci Neuroscience Cytoplasmic ribonucleoproteins called stress granules (SGs) are considered as one of the main cellular solutions against stress. Their temporary presence ends with stress relief. Any factor such as chronic stress or mutations in the structure of the components of SGs that lead to their permanent presence can affect their interactions with pathological aggregations and increase the degenerative effects. SGs involved in RNA mechanisms are important factors in the pathophysiology of neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS), frontotemporal degeneration (FTD), and Alzheimer's diseases (AD). Although many studies have been performed in the field of SGs and neurodegenerative disorders, so far, no systematic studies have been executed in this field. The purpose of this study is to provide a comprehensive perspective of all studies about the role of SGs in the pathogenesis of neurodegenerative disorders with a focus on the protein ingredients of these granules. This scoping review is based on a six-stage methodology structure and the PRISMA guideline. A systematic search of seven databases for qualified articles was conducted until December 2020. Publications were screened independently by two reviewers and quantitative and qualitative analysis was performed on the extracted data. Bioinformatics analysis was used to plot the network and predict interprotein interactions. In addition, GO analysis was performed. A total of 48 articles were identified that comply the inclusion criteria. Most studies on neurodegenerative diseases have been conducted on ALS, AD, and FTD using human post mortem tissues. Human derived cell line studies have been used only in ALS. A total 29 genes of protein components of SGs have been studied, the most important of which are TDP-43, TIA-1, PABP-1. Bioinformatics studies have predicted 15 proteins to interact with the protein components of SGs, which may be the constituents of SGs. Understanding the interactions between SGs and pathological aggregations in neurodegenerative diseases can provide new targets for treatment of these disorders. Frontiers Media S.A. 2021-06-23 /pmc/articles/PMC8261063/ /pubmed/34248597 http://dx.doi.org/10.3389/fnagi.2021.650740 Text en Copyright © 2021 Asadi, Sadat Moslehian, Sabaie, Jalaiei, Ghafouri-Fard, Taheri and Rezazadeh. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Asadi, Mohammad Reza Sadat Moslehian, Marziyeh Sabaie, Hani Jalaiei, Abbas Ghafouri-Fard, Soudeh Taheri, Mohammad Rezazadeh, Maryam Stress Granules and Neurodegenerative Disorders: A Scoping Review |
title | Stress Granules and Neurodegenerative Disorders: A Scoping Review |
title_full | Stress Granules and Neurodegenerative Disorders: A Scoping Review |
title_fullStr | Stress Granules and Neurodegenerative Disorders: A Scoping Review |
title_full_unstemmed | Stress Granules and Neurodegenerative Disorders: A Scoping Review |
title_short | Stress Granules and Neurodegenerative Disorders: A Scoping Review |
title_sort | stress granules and neurodegenerative disorders: a scoping review |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261063/ https://www.ncbi.nlm.nih.gov/pubmed/34248597 http://dx.doi.org/10.3389/fnagi.2021.650740 |
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