mRNA-encoded, constitutively active STING(V155M) is a potent genetic adjuvant of antigen-specific CD8(+) T cell response

mRNA vaccines induce potent immune responses in preclinical models and clinical studies. Adjuvants are used to stimulate specific components of the immune system to increase immunogenicity of vaccines. We utilized a constitutively active mutation (V155M) of the stimulator of interferon (IFN) genes (...

Descripción completa

Detalles Bibliográficos
Autores principales: Tse, Sze-Wah, McKinney, Kristine, Walker, William, Nguyen, Mychael, Iacovelli, Jared, Small, Clayton, Hopson, Kristen, Zaks, Tal, Huang, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261085/
https://www.ncbi.nlm.nih.gov/pubmed/33677092
http://dx.doi.org/10.1016/j.ymthe.2021.03.002

Ejemplares similares

Ejemplares similares