Cargando…
Cytokine Imprint in Preeclampsia
The hallmark of preeclampsia (PE) is a shift toward persistent inflammatory response, accompanied by endothelial dysfunction. The driving forces in PE are proinflammatory cytokine and growth factors, in parallel with reduced functionality of anti-inflammatory effectors, like regulatory T cells are o...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261231/ https://www.ncbi.nlm.nih.gov/pubmed/34248946 http://dx.doi.org/10.3389/fimmu.2021.667841 |
_version_ | 1783718971149647872 |
---|---|
author | Stefańska, Katarzyna Zieliński, Maciej Jankowiak, Martyna Zamkowska, Dorota Sakowska, Justyna Adamski, Przemysław Jassem-Bobowicz, Joanna Piekarska, Karolina Leszczyńska, Katarzyna Świątkowska-Stodulska, Renata Kwiatkowski, Sebastian Preis, Krzysztof Trzonkowski, Piotr Marek-Trzonkowska, Natalia |
author_facet | Stefańska, Katarzyna Zieliński, Maciej Jankowiak, Martyna Zamkowska, Dorota Sakowska, Justyna Adamski, Przemysław Jassem-Bobowicz, Joanna Piekarska, Karolina Leszczyńska, Katarzyna Świątkowska-Stodulska, Renata Kwiatkowski, Sebastian Preis, Krzysztof Trzonkowski, Piotr Marek-Trzonkowska, Natalia |
author_sort | Stefańska, Katarzyna |
collection | PubMed |
description | The hallmark of preeclampsia (PE) is a shift toward persistent inflammatory response, accompanied by endothelial dysfunction. The driving forces in PE are proinflammatory cytokine and growth factors, in parallel with reduced functionality of anti-inflammatory effectors, like regulatory T cells are observed. Unfortunately, no conclusive mechanism underlying preeclampsia has been identified. For this reason, research on preeclampsia is needed to provide a state of the art understanding of the pathophysiology, identification of new diagnostics tools and the development of targeted therapies. The 68 patients were divided into three groups: gestational hypertension (GH) group (n = 19) and PE group (n = 28) and a control group (n = 21). We have tested a set of 53 cytokines, chemokines and growth factors in preeclampsia and gestational hypertension, and then compared them with normal pregnancies. Using a diagnostic test assessment characteristic parameters (IL-22, MDC/CCL22, IL-2/IL-4 ratio) have been identified and cut-off values have been proposed to diagnose preeclampsia. All parameters had high negative or positive predictive values, above 80%. In conclusion, we have proposed a potential set of immune parameters to diagnose preeclampsia. |
format | Online Article Text |
id | pubmed-8261231 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82612312021-07-08 Cytokine Imprint in Preeclampsia Stefańska, Katarzyna Zieliński, Maciej Jankowiak, Martyna Zamkowska, Dorota Sakowska, Justyna Adamski, Przemysław Jassem-Bobowicz, Joanna Piekarska, Karolina Leszczyńska, Katarzyna Świątkowska-Stodulska, Renata Kwiatkowski, Sebastian Preis, Krzysztof Trzonkowski, Piotr Marek-Trzonkowska, Natalia Front Immunol Immunology The hallmark of preeclampsia (PE) is a shift toward persistent inflammatory response, accompanied by endothelial dysfunction. The driving forces in PE are proinflammatory cytokine and growth factors, in parallel with reduced functionality of anti-inflammatory effectors, like regulatory T cells are observed. Unfortunately, no conclusive mechanism underlying preeclampsia has been identified. For this reason, research on preeclampsia is needed to provide a state of the art understanding of the pathophysiology, identification of new diagnostics tools and the development of targeted therapies. The 68 patients were divided into three groups: gestational hypertension (GH) group (n = 19) and PE group (n = 28) and a control group (n = 21). We have tested a set of 53 cytokines, chemokines and growth factors in preeclampsia and gestational hypertension, and then compared them with normal pregnancies. Using a diagnostic test assessment characteristic parameters (IL-22, MDC/CCL22, IL-2/IL-4 ratio) have been identified and cut-off values have been proposed to diagnose preeclampsia. All parameters had high negative or positive predictive values, above 80%. In conclusion, we have proposed a potential set of immune parameters to diagnose preeclampsia. Frontiers Media S.A. 2021-06-23 /pmc/articles/PMC8261231/ /pubmed/34248946 http://dx.doi.org/10.3389/fimmu.2021.667841 Text en Copyright © 2021 Stefańska, Zieliński, Jankowiak, Zamkowska, Sakowska, Adamski, Jassem-Bobowicz, Piekarska, Leszczyńska, Świątkowska-Stodulska, Kwiatkowski, Preis, Trzonkowski and Marek-Trzonkowska https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Stefańska, Katarzyna Zieliński, Maciej Jankowiak, Martyna Zamkowska, Dorota Sakowska, Justyna Adamski, Przemysław Jassem-Bobowicz, Joanna Piekarska, Karolina Leszczyńska, Katarzyna Świątkowska-Stodulska, Renata Kwiatkowski, Sebastian Preis, Krzysztof Trzonkowski, Piotr Marek-Trzonkowska, Natalia Cytokine Imprint in Preeclampsia |
title | Cytokine Imprint in Preeclampsia |
title_full | Cytokine Imprint in Preeclampsia |
title_fullStr | Cytokine Imprint in Preeclampsia |
title_full_unstemmed | Cytokine Imprint in Preeclampsia |
title_short | Cytokine Imprint in Preeclampsia |
title_sort | cytokine imprint in preeclampsia |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261231/ https://www.ncbi.nlm.nih.gov/pubmed/34248946 http://dx.doi.org/10.3389/fimmu.2021.667841 |
work_keys_str_mv | AT stefanskakatarzyna cytokineimprintinpreeclampsia AT zielinskimaciej cytokineimprintinpreeclampsia AT jankowiakmartyna cytokineimprintinpreeclampsia AT zamkowskadorota cytokineimprintinpreeclampsia AT sakowskajustyna cytokineimprintinpreeclampsia AT adamskiprzemysław cytokineimprintinpreeclampsia AT jassembobowiczjoanna cytokineimprintinpreeclampsia AT piekarskakarolina cytokineimprintinpreeclampsia AT leszczynskakatarzyna cytokineimprintinpreeclampsia AT swiatkowskastodulskarenata cytokineimprintinpreeclampsia AT kwiatkowskisebastian cytokineimprintinpreeclampsia AT preiskrzysztof cytokineimprintinpreeclampsia AT trzonkowskipiotr cytokineimprintinpreeclampsia AT marektrzonkowskanatalia cytokineimprintinpreeclampsia |