Cargando…

Cytokine Imprint in Preeclampsia

The hallmark of preeclampsia (PE) is a shift toward persistent inflammatory response, accompanied by endothelial dysfunction. The driving forces in PE are proinflammatory cytokine and growth factors, in parallel with reduced functionality of anti-inflammatory effectors, like regulatory T cells are o...

Descripción completa

Detalles Bibliográficos
Autores principales: Stefańska, Katarzyna, Zieliński, Maciej, Jankowiak, Martyna, Zamkowska, Dorota, Sakowska, Justyna, Adamski, Przemysław, Jassem-Bobowicz, Joanna, Piekarska, Karolina, Leszczyńska, Katarzyna, Świątkowska-Stodulska, Renata, Kwiatkowski, Sebastian, Preis, Krzysztof, Trzonkowski, Piotr, Marek-Trzonkowska, Natalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261231/
https://www.ncbi.nlm.nih.gov/pubmed/34248946
http://dx.doi.org/10.3389/fimmu.2021.667841
_version_ 1783718971149647872
author Stefańska, Katarzyna
Zieliński, Maciej
Jankowiak, Martyna
Zamkowska, Dorota
Sakowska, Justyna
Adamski, Przemysław
Jassem-Bobowicz, Joanna
Piekarska, Karolina
Leszczyńska, Katarzyna
Świątkowska-Stodulska, Renata
Kwiatkowski, Sebastian
Preis, Krzysztof
Trzonkowski, Piotr
Marek-Trzonkowska, Natalia
author_facet Stefańska, Katarzyna
Zieliński, Maciej
Jankowiak, Martyna
Zamkowska, Dorota
Sakowska, Justyna
Adamski, Przemysław
Jassem-Bobowicz, Joanna
Piekarska, Karolina
Leszczyńska, Katarzyna
Świątkowska-Stodulska, Renata
Kwiatkowski, Sebastian
Preis, Krzysztof
Trzonkowski, Piotr
Marek-Trzonkowska, Natalia
author_sort Stefańska, Katarzyna
collection PubMed
description The hallmark of preeclampsia (PE) is a shift toward persistent inflammatory response, accompanied by endothelial dysfunction. The driving forces in PE are proinflammatory cytokine and growth factors, in parallel with reduced functionality of anti-inflammatory effectors, like regulatory T cells are observed. Unfortunately, no conclusive mechanism underlying preeclampsia has been identified. For this reason, research on preeclampsia is needed to provide a state of the art understanding of the pathophysiology, identification of new diagnostics tools and the development of targeted therapies. The 68 patients were divided into three groups: gestational hypertension (GH) group (n = 19) and PE group (n = 28) and a control group (n = 21). We have tested a set of 53 cytokines, chemokines and growth factors in preeclampsia and gestational hypertension, and then compared them with normal pregnancies. Using a diagnostic test assessment characteristic parameters (IL-22, MDC/CCL22, IL-2/IL-4 ratio) have been identified and cut-off values have been proposed to diagnose preeclampsia. All parameters had high negative or positive predictive values, above 80%. In conclusion, we have proposed a potential set of immune parameters to diagnose preeclampsia.
format Online
Article
Text
id pubmed-8261231
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-82612312021-07-08 Cytokine Imprint in Preeclampsia Stefańska, Katarzyna Zieliński, Maciej Jankowiak, Martyna Zamkowska, Dorota Sakowska, Justyna Adamski, Przemysław Jassem-Bobowicz, Joanna Piekarska, Karolina Leszczyńska, Katarzyna Świątkowska-Stodulska, Renata Kwiatkowski, Sebastian Preis, Krzysztof Trzonkowski, Piotr Marek-Trzonkowska, Natalia Front Immunol Immunology The hallmark of preeclampsia (PE) is a shift toward persistent inflammatory response, accompanied by endothelial dysfunction. The driving forces in PE are proinflammatory cytokine and growth factors, in parallel with reduced functionality of anti-inflammatory effectors, like regulatory T cells are observed. Unfortunately, no conclusive mechanism underlying preeclampsia has been identified. For this reason, research on preeclampsia is needed to provide a state of the art understanding of the pathophysiology, identification of new diagnostics tools and the development of targeted therapies. The 68 patients were divided into three groups: gestational hypertension (GH) group (n = 19) and PE group (n = 28) and a control group (n = 21). We have tested a set of 53 cytokines, chemokines and growth factors in preeclampsia and gestational hypertension, and then compared them with normal pregnancies. Using a diagnostic test assessment characteristic parameters (IL-22, MDC/CCL22, IL-2/IL-4 ratio) have been identified and cut-off values have been proposed to diagnose preeclampsia. All parameters had high negative or positive predictive values, above 80%. In conclusion, we have proposed a potential set of immune parameters to diagnose preeclampsia. Frontiers Media S.A. 2021-06-23 /pmc/articles/PMC8261231/ /pubmed/34248946 http://dx.doi.org/10.3389/fimmu.2021.667841 Text en Copyright © 2021 Stefańska, Zieliński, Jankowiak, Zamkowska, Sakowska, Adamski, Jassem-Bobowicz, Piekarska, Leszczyńska, Świątkowska-Stodulska, Kwiatkowski, Preis, Trzonkowski and Marek-Trzonkowska https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Stefańska, Katarzyna
Zieliński, Maciej
Jankowiak, Martyna
Zamkowska, Dorota
Sakowska, Justyna
Adamski, Przemysław
Jassem-Bobowicz, Joanna
Piekarska, Karolina
Leszczyńska, Katarzyna
Świątkowska-Stodulska, Renata
Kwiatkowski, Sebastian
Preis, Krzysztof
Trzonkowski, Piotr
Marek-Trzonkowska, Natalia
Cytokine Imprint in Preeclampsia
title Cytokine Imprint in Preeclampsia
title_full Cytokine Imprint in Preeclampsia
title_fullStr Cytokine Imprint in Preeclampsia
title_full_unstemmed Cytokine Imprint in Preeclampsia
title_short Cytokine Imprint in Preeclampsia
title_sort cytokine imprint in preeclampsia
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261231/
https://www.ncbi.nlm.nih.gov/pubmed/34248946
http://dx.doi.org/10.3389/fimmu.2021.667841
work_keys_str_mv AT stefanskakatarzyna cytokineimprintinpreeclampsia
AT zielinskimaciej cytokineimprintinpreeclampsia
AT jankowiakmartyna cytokineimprintinpreeclampsia
AT zamkowskadorota cytokineimprintinpreeclampsia
AT sakowskajustyna cytokineimprintinpreeclampsia
AT adamskiprzemysław cytokineimprintinpreeclampsia
AT jassembobowiczjoanna cytokineimprintinpreeclampsia
AT piekarskakarolina cytokineimprintinpreeclampsia
AT leszczynskakatarzyna cytokineimprintinpreeclampsia
AT swiatkowskastodulskarenata cytokineimprintinpreeclampsia
AT kwiatkowskisebastian cytokineimprintinpreeclampsia
AT preiskrzysztof cytokineimprintinpreeclampsia
AT trzonkowskipiotr cytokineimprintinpreeclampsia
AT marektrzonkowskanatalia cytokineimprintinpreeclampsia