Liver-Directed AAV8 Booster Vaccine Expressing Plasmodium falciparum Antigen Following Adenovirus Vaccine Priming Elicits Sterile Protection in a Murine Model

Hepatocyte infection by malaria sporozoites is a bottleneck in the life-cycle of Plasmodium spp. including P. falciparum, which causes the most lethal form of malaria. Therefore, developing an effective vaccine capable of inducing the strong humoral and cellular immune responses necessary to block t...

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Detalles Bibliográficos
Autores principales: Shahnaij, Mohammad, Iyori, Mitsuhiro, Mizukami, Hiroaki, Kajino, Mayu, Yamagoshi, Iroha, Syafira, Intan, Yusuf, Yenni, Fujiwara, Ken, Yamamoto, Daisuke S., Kato, Hirotomo, Ohno, Nobuhiko, Yoshida, Shigeto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261234/
https://www.ncbi.nlm.nih.gov/pubmed/34248928
http://dx.doi.org/10.3389/fimmu.2021.612910

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261234/
https://www.ncbi.nlm.nih.gov/pubmed/34248928
http://dx.doi.org/10.3389/fimmu.2021.612910

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