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Adenomatoid Tumor of the Adrenal Gland: Report of Two Cases and Review of the Literature

Adenomatoid tumor (AT) is an uncommon benign neoplasm of mesothelial origin, usually occurring in the female and male genital tracts. Extragenital localization such as the adrenal gland is extremely rare. Until now, only 39 cases of adrenal AT have been reported in the English literature. Here we re...

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Autores principales: Guan, Jiexia, Zhao, Chang, Li, Hengming, Zhang, Wenjing, Lin, Weizhen, Tang, Luying, Chen, Jianning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261242/
https://www.ncbi.nlm.nih.gov/pubmed/34248850
http://dx.doi.org/10.3389/fendo.2021.692553
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author Guan, Jiexia
Zhao, Chang
Li, Hengming
Zhang, Wenjing
Lin, Weizhen
Tang, Luying
Chen, Jianning
author_facet Guan, Jiexia
Zhao, Chang
Li, Hengming
Zhang, Wenjing
Lin, Weizhen
Tang, Luying
Chen, Jianning
author_sort Guan, Jiexia
collection PubMed
description Adenomatoid tumor (AT) is an uncommon benign neoplasm of mesothelial origin, usually occurring in the female and male genital tracts. Extragenital localization such as the adrenal gland is extremely rare. Until now, only 39 cases of adrenal AT have been reported in the English literature. Here we report two novel cases of adrenal AT that occurred in male patients aged 30 and 31 years. The tumors were discovered incidentally by computed tomography (CT). Macroscopically, the tumors were unilateral and solid, and the greatest dimension of the tumors was 3.5 and 8.0 cm, respectively. Histologically, the tumors consisted of angiomatoid, cystic, and solid patterns and infiltrated the adrenal cortical or medullary tissue. The tumor cells had low nuclear/cytoplasmic ratio, with no pathological mitosis or nuclear pleomorphism. Thread-like bridging strands and signet-ring-like cells could be seen. Immunohistochemically, the tumor cells were positive for epithelial markers (AE1/AE3, CK7) and mesothelial markers (D2-40, calretinin, and WT-1). The Ki-67 index was approximately 1 and 2%, respectively. The differential diagnosis of adrenal AT includes a variety of benign and malignant tumors. The patients had neither local recurrence nor distant metastasis at 21 and 8 months after removal of the tumor. In the literature review, we comprehensively summarized the clinical, morphological, immunohistochemical, and prognostic features of adrenal AT. Adrenal ATs are morphologically and immunophenotypically identical to those that occur in the genital tracts. Combining the histology with immunohistochemical profiles is very supportive in reaching the diagnosis of this benign tumor, helping to avoid misdiagnosis and overtreatment.
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spelling pubmed-82612422021-07-08 Adenomatoid Tumor of the Adrenal Gland: Report of Two Cases and Review of the Literature Guan, Jiexia Zhao, Chang Li, Hengming Zhang, Wenjing Lin, Weizhen Tang, Luying Chen, Jianning Front Endocrinol (Lausanne) Endocrinology Adenomatoid tumor (AT) is an uncommon benign neoplasm of mesothelial origin, usually occurring in the female and male genital tracts. Extragenital localization such as the adrenal gland is extremely rare. Until now, only 39 cases of adrenal AT have been reported in the English literature. Here we report two novel cases of adrenal AT that occurred in male patients aged 30 and 31 years. The tumors were discovered incidentally by computed tomography (CT). Macroscopically, the tumors were unilateral and solid, and the greatest dimension of the tumors was 3.5 and 8.0 cm, respectively. Histologically, the tumors consisted of angiomatoid, cystic, and solid patterns and infiltrated the adrenal cortical or medullary tissue. The tumor cells had low nuclear/cytoplasmic ratio, with no pathological mitosis or nuclear pleomorphism. Thread-like bridging strands and signet-ring-like cells could be seen. Immunohistochemically, the tumor cells were positive for epithelial markers (AE1/AE3, CK7) and mesothelial markers (D2-40, calretinin, and WT-1). The Ki-67 index was approximately 1 and 2%, respectively. The differential diagnosis of adrenal AT includes a variety of benign and malignant tumors. The patients had neither local recurrence nor distant metastasis at 21 and 8 months after removal of the tumor. In the literature review, we comprehensively summarized the clinical, morphological, immunohistochemical, and prognostic features of adrenal AT. Adrenal ATs are morphologically and immunophenotypically identical to those that occur in the genital tracts. Combining the histology with immunohistochemical profiles is very supportive in reaching the diagnosis of this benign tumor, helping to avoid misdiagnosis and overtreatment. Frontiers Media S.A. 2021-06-23 /pmc/articles/PMC8261242/ /pubmed/34248850 http://dx.doi.org/10.3389/fendo.2021.692553 Text en Copyright © 2021 Guan, Zhao, Li, Zhang, Lin, Tang and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Guan, Jiexia
Zhao, Chang
Li, Hengming
Zhang, Wenjing
Lin, Weizhen
Tang, Luying
Chen, Jianning
Adenomatoid Tumor of the Adrenal Gland: Report of Two Cases and Review of the Literature
title Adenomatoid Tumor of the Adrenal Gland: Report of Two Cases and Review of the Literature
title_full Adenomatoid Tumor of the Adrenal Gland: Report of Two Cases and Review of the Literature
title_fullStr Adenomatoid Tumor of the Adrenal Gland: Report of Two Cases and Review of the Literature
title_full_unstemmed Adenomatoid Tumor of the Adrenal Gland: Report of Two Cases and Review of the Literature
title_short Adenomatoid Tumor of the Adrenal Gland: Report of Two Cases and Review of the Literature
title_sort adenomatoid tumor of the adrenal gland: report of two cases and review of the literature
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261242/
https://www.ncbi.nlm.nih.gov/pubmed/34248850
http://dx.doi.org/10.3389/fendo.2021.692553
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