Identification of Novel Environmental Substances Relevant to Pediatric Graves’ Disease

Graves’ disease (GD) is the most common cause of hyperthyroidism, yet a relatively rare disease in the pediatric population. GD is a complex disorder influenced by both genetic and environmental factors. In this study, we aimed to find new environmental factors influencing the pathogenesis of GD. We...

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Autores principales: Xia, Qin, Liu, Jingjing, Xu, Xu, Gu, Wei, Gu, Kefeng, Chen, Xiuli, Xie, Rongrong, Zhang, Dandan, Wu, Haiying, Sun, Hui, Wang, Fengyun, Chen, Linqi, Chen, Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261246/
https://www.ncbi.nlm.nih.gov/pubmed/34248849
http://dx.doi.org/10.3389/fendo.2021.691326
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author Xia, Qin
Liu, Jingjing
Xu, Xu
Gu, Wei
Gu, Kefeng
Chen, Xiuli
Xie, Rongrong
Zhang, Dandan
Wu, Haiying
Sun, Hui
Wang, Fengyun
Chen, Linqi
Chen, Ting
author_facet Xia, Qin
Liu, Jingjing
Xu, Xu
Gu, Wei
Gu, Kefeng
Chen, Xiuli
Xie, Rongrong
Zhang, Dandan
Wu, Haiying
Sun, Hui
Wang, Fengyun
Chen, Linqi
Chen, Ting
author_sort Xia, Qin
collection PubMed
description Graves’ disease (GD) is the most common cause of hyperthyroidism, yet a relatively rare disease in the pediatric population. GD is a complex disorder influenced by both genetic and environmental factors. In this study, we aimed to find new environmental factors influencing the pathogenesis of GD. We investigated serum substances in 30 newly diagnosed GD children and 30 age- and gender-matched healthy controls. We measured total iodine by inductively coupled plasma-mass spectrometry (ICP-MS), analyzed perfluorinated compounds via ultra-high-performance liquid chromatography coupled with multiple reaction monitoring mass spectrometry (UHPLC-MRM-MS), and explored other environmental substances using ultra-high-performance liquid chromatography–quadrupole time-of-flight mass spectrometry (UHPLC–QTOF/MS) analysis. Twenty-nine single-nucleotide polymorphisms (SNPs) in eight genes related to GD were analyzed by SNaPshot. The serum total iodine was significantly higher in GD group, but its association with GD onset was weak, only with Exp(B) value near 1. The perfluorinated compound levels were not different between the two groups. More importantly, we found 16 environmental substances significantly different between GD and control groups, among which ponasterone A is a risk factor (p = 0.007 and Exp(B) = 14.14), while confertifoline is a protective factor against GD onset (p = 0.002 and Exp(B) = 0.001). We also identified 10 substances correlated significantly with thyroid indices in GD patients, among which seven associated with levels of the thyroid autoantibody TPOAb. No known SNPs were found predisposing GD. In this study, we explored a broad variety of environmental substances and identified novel factors that are potentially involved in the pediatric GD pathogenesis.
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spelling pubmed-82612462021-07-08 Identification of Novel Environmental Substances Relevant to Pediatric Graves’ Disease Xia, Qin Liu, Jingjing Xu, Xu Gu, Wei Gu, Kefeng Chen, Xiuli Xie, Rongrong Zhang, Dandan Wu, Haiying Sun, Hui Wang, Fengyun Chen, Linqi Chen, Ting Front Endocrinol (Lausanne) Endocrinology Graves’ disease (GD) is the most common cause of hyperthyroidism, yet a relatively rare disease in the pediatric population. GD is a complex disorder influenced by both genetic and environmental factors. In this study, we aimed to find new environmental factors influencing the pathogenesis of GD. We investigated serum substances in 30 newly diagnosed GD children and 30 age- and gender-matched healthy controls. We measured total iodine by inductively coupled plasma-mass spectrometry (ICP-MS), analyzed perfluorinated compounds via ultra-high-performance liquid chromatography coupled with multiple reaction monitoring mass spectrometry (UHPLC-MRM-MS), and explored other environmental substances using ultra-high-performance liquid chromatography–quadrupole time-of-flight mass spectrometry (UHPLC–QTOF/MS) analysis. Twenty-nine single-nucleotide polymorphisms (SNPs) in eight genes related to GD were analyzed by SNaPshot. The serum total iodine was significantly higher in GD group, but its association with GD onset was weak, only with Exp(B) value near 1. The perfluorinated compound levels were not different between the two groups. More importantly, we found 16 environmental substances significantly different between GD and control groups, among which ponasterone A is a risk factor (p = 0.007 and Exp(B) = 14.14), while confertifoline is a protective factor against GD onset (p = 0.002 and Exp(B) = 0.001). We also identified 10 substances correlated significantly with thyroid indices in GD patients, among which seven associated with levels of the thyroid autoantibody TPOAb. No known SNPs were found predisposing GD. In this study, we explored a broad variety of environmental substances and identified novel factors that are potentially involved in the pediatric GD pathogenesis. Frontiers Media S.A. 2021-06-23 /pmc/articles/PMC8261246/ /pubmed/34248849 http://dx.doi.org/10.3389/fendo.2021.691326 Text en Copyright © 2021 Xia, Liu, Xu, Gu, Gu, Chen, Xie, Zhang, Wu, Sun, Wang, Chen and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Xia, Qin
Liu, Jingjing
Xu, Xu
Gu, Wei
Gu, Kefeng
Chen, Xiuli
Xie, Rongrong
Zhang, Dandan
Wu, Haiying
Sun, Hui
Wang, Fengyun
Chen, Linqi
Chen, Ting
Identification of Novel Environmental Substances Relevant to Pediatric Graves’ Disease
title Identification of Novel Environmental Substances Relevant to Pediatric Graves’ Disease
title_full Identification of Novel Environmental Substances Relevant to Pediatric Graves’ Disease
title_fullStr Identification of Novel Environmental Substances Relevant to Pediatric Graves’ Disease
title_full_unstemmed Identification of Novel Environmental Substances Relevant to Pediatric Graves’ Disease
title_short Identification of Novel Environmental Substances Relevant to Pediatric Graves’ Disease
title_sort identification of novel environmental substances relevant to pediatric graves’ disease
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261246/
https://www.ncbi.nlm.nih.gov/pubmed/34248849
http://dx.doi.org/10.3389/fendo.2021.691326
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