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Inactivation of the Euchromatic Histone-Lysine N-Methyltransferase 2 Pathway in Pancreatic Epithelial Cells Antagonizes Cancer Initiation and Pancreatitis-Associated Promotion by Altering Growth and Immune Gene Expression Networks

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, painful disease with a 5-year survival rate of only 9%. Recent evidence indicates that distinct epigenomic landscapes underlie PDAC progression, identifying the H3K9me pathway as important to its pathobiology. Here, we delineate the role of E...

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Detalles Bibliográficos
Autores principales:	Urrutia, Guillermo, de Assuncao, Thiago Milech, Mathison, Angela J., Salmonson, Ann, Kerketta, Romica, Zeighami, Atefeh, Stodola, Timothy J., Adsay, Volkan, Pehlivanoglu, Burcin, Dwinell, Michael B., Zimmermann, Michael T., Iovanna, Juan L., Urrutia, Raul, Lomberk, Gwen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261250/ https://www.ncbi.nlm.nih.gov/pubmed/34249932 http://dx.doi.org/10.3389/fcell.2021.681153

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