Cargando…

Allergic Asthma-Induced Cognitive Impairment is Alleviated by Dexamethasone

Allergic asthma is a typical chronic inflammatory disease of respiratory tract. Clinical data shows that patients with allergic asthma have different degrees of cognitive dysfunction. The molecular mechanism underlying the pathogenesis of asthma-induced cognitive disorder is not yet well defined. De...

Descripción completa

Detalles Bibliográficos
Autores principales: Ren, Mengli, Feng, Min, Long, Zhimin, Ma, Jing, Peng, Xuehua, He, Guiqiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261293/
https://www.ncbi.nlm.nih.gov/pubmed/34248632
http://dx.doi.org/10.3389/fphar.2021.680815
_version_ 1783718985214197760
author Ren, Mengli
Feng, Min
Long, Zhimin
Ma, Jing
Peng, Xuehua
He, Guiqiong
author_facet Ren, Mengli
Feng, Min
Long, Zhimin
Ma, Jing
Peng, Xuehua
He, Guiqiong
author_sort Ren, Mengli
collection PubMed
description Allergic asthma is a typical chronic inflammatory disease of respiratory tract. Clinical data shows that patients with allergic asthma have different degrees of cognitive dysfunction. The molecular mechanism underlying the pathogenesis of asthma-induced cognitive disorder is not yet well defined. Dexamethasone (DEX), one of the first-line drugs being widely used in the treatment of asthma, has not been reported to have an effect on cognitive dysfunction in mice model. To investigate the effect of asthma on cognitive impairment as well as the effect of DEX on asthma-caused morphological and behavioral changes, C57BL/6J mice received treatment with house dust mites (HDM) for 60 days to become allergic asthma model mice, and a group of HDM-treated asthma model mice were treated with DEX. HDM-treated asthma model mice exhibited increased airway hyperresponsiveness (AHR) and inflammatory infiltration in lung tissue. An elevated level of IL-4, IL-5, and TNF-α was detected in bronchoalveolar lavage fluid (BALF) by Luminex liquid suspension chip. Asthma model mice also presented memory deficits accompanied with morphological changes at the synaptic levels in the cortex and hippocampus. Meanwhile, vascular edema and increased expression of HIF-1α and HIF-2α were found in the brain of asthma model mice. Interestingly, DEX treatment could reverse the inflammatory changes in asthma model mice airway, rescue the cognitive impairment and improve the synaptic plasticity. Besides, DEX significantly decreased the expression of HIF-1α and HIF-2α in mice brain and lung. These processes may be used to decipher the complex interplay and pathological changes between asthma and cognition. This study provides laboratory evidence for the prevention and treatment of cognitive malfunction induced by asthma.
format Online
Article
Text
id pubmed-8261293
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-82612932021-07-08 Allergic Asthma-Induced Cognitive Impairment is Alleviated by Dexamethasone Ren, Mengli Feng, Min Long, Zhimin Ma, Jing Peng, Xuehua He, Guiqiong Front Pharmacol Pharmacology Allergic asthma is a typical chronic inflammatory disease of respiratory tract. Clinical data shows that patients with allergic asthma have different degrees of cognitive dysfunction. The molecular mechanism underlying the pathogenesis of asthma-induced cognitive disorder is not yet well defined. Dexamethasone (DEX), one of the first-line drugs being widely used in the treatment of asthma, has not been reported to have an effect on cognitive dysfunction in mice model. To investigate the effect of asthma on cognitive impairment as well as the effect of DEX on asthma-caused morphological and behavioral changes, C57BL/6J mice received treatment with house dust mites (HDM) for 60 days to become allergic asthma model mice, and a group of HDM-treated asthma model mice were treated with DEX. HDM-treated asthma model mice exhibited increased airway hyperresponsiveness (AHR) and inflammatory infiltration in lung tissue. An elevated level of IL-4, IL-5, and TNF-α was detected in bronchoalveolar lavage fluid (BALF) by Luminex liquid suspension chip. Asthma model mice also presented memory deficits accompanied with morphological changes at the synaptic levels in the cortex and hippocampus. Meanwhile, vascular edema and increased expression of HIF-1α and HIF-2α were found in the brain of asthma model mice. Interestingly, DEX treatment could reverse the inflammatory changes in asthma model mice airway, rescue the cognitive impairment and improve the synaptic plasticity. Besides, DEX significantly decreased the expression of HIF-1α and HIF-2α in mice brain and lung. These processes may be used to decipher the complex interplay and pathological changes between asthma and cognition. This study provides laboratory evidence for the prevention and treatment of cognitive malfunction induced by asthma. Frontiers Media S.A. 2021-06-23 /pmc/articles/PMC8261293/ /pubmed/34248632 http://dx.doi.org/10.3389/fphar.2021.680815 Text en Copyright © 2021 Ren, Feng, Long, Ma, Peng and He. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Ren, Mengli
Feng, Min
Long, Zhimin
Ma, Jing
Peng, Xuehua
He, Guiqiong
Allergic Asthma-Induced Cognitive Impairment is Alleviated by Dexamethasone
title Allergic Asthma-Induced Cognitive Impairment is Alleviated by Dexamethasone
title_full Allergic Asthma-Induced Cognitive Impairment is Alleviated by Dexamethasone
title_fullStr Allergic Asthma-Induced Cognitive Impairment is Alleviated by Dexamethasone
title_full_unstemmed Allergic Asthma-Induced Cognitive Impairment is Alleviated by Dexamethasone
title_short Allergic Asthma-Induced Cognitive Impairment is Alleviated by Dexamethasone
title_sort allergic asthma-induced cognitive impairment is alleviated by dexamethasone
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261293/
https://www.ncbi.nlm.nih.gov/pubmed/34248632
http://dx.doi.org/10.3389/fphar.2021.680815
work_keys_str_mv AT renmengli allergicasthmainducedcognitiveimpairmentisalleviatedbydexamethasone
AT fengmin allergicasthmainducedcognitiveimpairmentisalleviatedbydexamethasone
AT longzhimin allergicasthmainducedcognitiveimpairmentisalleviatedbydexamethasone
AT majing allergicasthmainducedcognitiveimpairmentisalleviatedbydexamethasone
AT pengxuehua allergicasthmainducedcognitiveimpairmentisalleviatedbydexamethasone
AT heguiqiong allergicasthmainducedcognitiveimpairmentisalleviatedbydexamethasone