SARS-CoV-2/ACE2 Interaction Suppresses IRAK-M Expression and Promotes Pro-Inflammatory Cytokine Production in Macrophages

The major cause of death in SARS-CoV-2 infected patients is due to de-regulation of the innate immune system and development of cytokine storm. SARS-CoV-2 infects multiple cell types in the lung, including macrophages, by engagement of its spike (S) protein on angiotensin converting enzyme 2 (ACE2)...

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Detalles Bibliográficos
Autores principales: Pantazi, Ioanna, Al-Qahtani, Ahmed A., Alhamlan, Fatimah S, Alothaid, Hani, Matou-Nasri, Sabine, Sourvinos, George, Vergadi, Eleni, Tsatsanis, Christos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261299/
https://www.ncbi.nlm.nih.gov/pubmed/34248968
http://dx.doi.org/10.3389/fimmu.2021.683800

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261299/
https://www.ncbi.nlm.nih.gov/pubmed/34248968
http://dx.doi.org/10.3389/fimmu.2021.683800

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