A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy

The FZD4:LRP5:TSPAN12 receptor complex is activated by the secreted protein Norrin in retinal endothelial cells and leads to βcatenin‐dependent formation of the blood–retina–barrier during development and its homeostasis in adults. Mutations disrupting Norrin signaling have been identified in severa...

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Detalles Bibliográficos
Autores principales: Chidiac, Rony, Abedin, Md., Macleod, Graham, Yang, Andy, Thibeault, Pierre E, Blazer, Levi L, Adams, Jarrett J, Zhang, Lingling, Roehrich, Heidi, Jo, Ha‐Neul, Seshagiri, Somasekar, Sidhu, Sachdev S, Junge, Harald J, Angers, Stephane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261507/
https://www.ncbi.nlm.nih.gov/pubmed/34105895
http://dx.doi.org/10.15252/emmm.202113977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261507/
https://www.ncbi.nlm.nih.gov/pubmed/34105895
http://dx.doi.org/10.15252/emmm.202113977

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