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A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy
The FZD4:LRP5:TSPAN12 receptor complex is activated by the secreted protein Norrin in retinal endothelial cells and leads to βcatenin‐dependent formation of the blood–retina–barrier during development and its homeostasis in adults. Mutations disrupting Norrin signaling have been identified in severa...
Autores principales: | Chidiac, Rony, Abedin, Md., Macleod, Graham, Yang, Andy, Thibeault, Pierre E, Blazer, Levi L, Adams, Jarrett J, Zhang, Lingling, Roehrich, Heidi, Jo, Ha‐Neul, Seshagiri, Somasekar, Sidhu, Sachdev S, Junge, Harald J, Angers, Stephane |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261507/ https://www.ncbi.nlm.nih.gov/pubmed/34105895 http://dx.doi.org/10.15252/emmm.202113977 |
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