Atherosclerosis-associated hepatic secretion of VLDL but not PCSK9 is dependent on cargo receptor protein Surf4

Plasma LDL is produced from catabolism of VLDL and cleared from circulation mainly via the hepatic LDL receptor (LDLR). Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes LDLR degradation, increasing plasma LDL-C levels. Circulating PCSK9 is mainly secreted by the liver, whereas VLDL is...

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Detalles Bibliográficos
Autores principales: Wang, Bingxiang, Shen, Yishi, Zhai, Lei, Xia, Xiaodan, Gu, Hong-mei, Wang, Maggie, Zhao, Yongfang, Chang, Xiaole, Alabi, Adekunle, Xing, Sijie, Deng, Shijun, Liu, Boyan, Wang, Guiqing, Qin, Shucun, Zhang, Da-wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261665/
https://www.ncbi.nlm.nih.gov/pubmed/34118252
http://dx.doi.org/10.1016/j.jlr.2021.100091

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