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Reduced eIF4E function impairs B-cell leukemia without altering normal B-lymphocyte function

The cap-binding protein eukaryotic initiation factor 4E (eIF4E) promotes translation of mRNAs associated with proliferation and survival and is an attractive target for cancer therapeutics. Here, we used Eif4e germline and conditional knockout models to assess the impact of reduced Eif4e gene dosage...

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Detalles Bibliográficos
Autores principales:	Chiu, Honyin, Buono, Roberta, Jackson, Leandra V., Herzog, Lee-or, Mallya, Sharmila, Conn, Crystal S., Ruggero, Davide, Fruman, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261676/ https://www.ncbi.nlm.nih.gov/pubmed/34278258 http://dx.doi.org/10.1016/j.isci.2021.102748

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