Association of Apolipoprotein E ɛ4 Allele With Clinical and Multimodal Biomarker Changes of Alzheimer Disease in Adults With Down Syndrome

IMPORTANCE: Alzheimer disease (AD) is the leading cause of death in individuals with Down syndrome (DS). Previous studies have suggested that the APOE ɛ4 allele plays a role in the risk and age at onset of dementia in DS; however, data on in vivo biomarkers remain scarce. OBJECTIVE: To investigate t...

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Detalles Bibliográficos
Autores principales: Bejanin, Alexandre, Iulita, Maria Florencia, Vilaplana, Eduard, Carmona-Iragui, Maria, Benejam, Bessy, Videla, Laura, Barroeta, Isabel, Fernandez, Susana, Altuna, Miren, Pegueroles, Jordi, Montal, Victor, Valldeneu, Silvia, Giménez, Sandra, González-Ortiz, Sofía, Muñoz, Laia, Padilla, Concepción, Aranha, Mateus Rozalem, Estellés, Teresa, Illán-Gala, Ignacio, Belbin, Olivia, Camacho, Valle, Wilson, Liam Reese, Annus, Tiina, Osorio, Ricardo S., Videla, Sebastián, Lehmann, Sylvain, Holland, Anthony J., Zetterberg, Henrik, Blennow, Kaj, Alcolea, Daniel, Clarimon, Jordi, Zaman, Shahid H., Blesa, Rafael, Lleó, Alberto, Fortea, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2021
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261691/
https://www.ncbi.nlm.nih.gov/pubmed/34228042
http://dx.doi.org/10.1001/jamaneurol.2021.1893

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