Mechanical characterization of base analogue modified nucleic acids by force spectroscopy

We use mechanical unfolding of single DNA hairpins with modified bases to accurately assess intra- and intermolecular forces in nucleic acids. As expected, the modification stabilizes the hybridized hairpin, but we also observe intriguing stacking interactions in the unfolded hairpin. Our study high...

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Detalles Bibliográficos
Autores principales: Sundar Rajan, Vinoth, Viader-Godoy, Xavier, Lin, Yii-Lih, Dutta, Uttama, Ritort, Felix, Westerlund, Fredrik, Wilhelmsson, L. Marcus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261857/
https://www.ncbi.nlm.nih.gov/pubmed/34180930
http://dx.doi.org/10.1039/d1cp01985f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261857/
https://www.ncbi.nlm.nih.gov/pubmed/34180930
http://dx.doi.org/10.1039/d1cp01985f

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