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Anxiety and depression in inflammatory eye disease: exploring the potential impact of topical treatment frequency as a putative psychometric item

OBJECTIVE: To evaluate whether topical therapy is linked to scores related to anxiety, depression and quality of life (QoL) in inflammatory eye disease (IED). METHODS AND ANALYSIS: Patients with ocular surface disease (OSD, N=100) and Uveitis (N=100) completed self-administered validated questions o...

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Autores principales: Vakros, Georgios, Scollo, Paolo, Hodson, James, Murray, Philip I, Rauz, Saaeha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261890/
https://www.ncbi.nlm.nih.gov/pubmed/34307892
http://dx.doi.org/10.1136/bmjophth-2020-000649
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author Vakros, Georgios
Scollo, Paolo
Hodson, James
Murray, Philip I
Rauz, Saaeha
author_facet Vakros, Georgios
Scollo, Paolo
Hodson, James
Murray, Philip I
Rauz, Saaeha
author_sort Vakros, Georgios
collection PubMed
description OBJECTIVE: To evaluate whether topical therapy is linked to scores related to anxiety, depression and quality of life (QoL) in inflammatory eye disease (IED). METHODS AND ANALYSIS: Patients with ocular surface disease (OSD, N=100) and Uveitis (N=100) completed self-administered validated questions on ocular symptoms and well-being, with supplemental questions on eye drop frequency. RESULTS: Forty (20%) patients had scores consistent with depression and 33 (17%) anxiety. Anxiety, depression, QoL and OSD index (OSDI) scores did not differ significantly between OSD and Uveitis groups. In those with anxiety or depression, QoL was significantly reduced in all WHO Quality Of Life-BREF domains (all p<0.001). Multivariable analysis considering demographic and disease-related factors found daily topical drop frequency to be independently associated with anxiety (p=0.009) but not depression (p=0.300). CONCLUSION: A high proportion of patients with IED demonstrated scores indicative of anxiety and depression. Preliminary evidence suggests that the frequency of topical eye drops potentially plays a significant role in the psychological health status of patients with IED.
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spelling pubmed-82618902021-07-23 Anxiety and depression in inflammatory eye disease: exploring the potential impact of topical treatment frequency as a putative psychometric item Vakros, Georgios Scollo, Paolo Hodson, James Murray, Philip I Rauz, Saaeha BMJ Open Ophthalmol Vision Science OBJECTIVE: To evaluate whether topical therapy is linked to scores related to anxiety, depression and quality of life (QoL) in inflammatory eye disease (IED). METHODS AND ANALYSIS: Patients with ocular surface disease (OSD, N=100) and Uveitis (N=100) completed self-administered validated questions on ocular symptoms and well-being, with supplemental questions on eye drop frequency. RESULTS: Forty (20%) patients had scores consistent with depression and 33 (17%) anxiety. Anxiety, depression, QoL and OSD index (OSDI) scores did not differ significantly between OSD and Uveitis groups. In those with anxiety or depression, QoL was significantly reduced in all WHO Quality Of Life-BREF domains (all p<0.001). Multivariable analysis considering demographic and disease-related factors found daily topical drop frequency to be independently associated with anxiety (p=0.009) but not depression (p=0.300). CONCLUSION: A high proportion of patients with IED demonstrated scores indicative of anxiety and depression. Preliminary evidence suggests that the frequency of topical eye drops potentially plays a significant role in the psychological health status of patients with IED. BMJ Publishing Group 2021-07-06 /pmc/articles/PMC8261890/ /pubmed/34307892 http://dx.doi.org/10.1136/bmjophth-2020-000649 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Vision Science
Vakros, Georgios
Scollo, Paolo
Hodson, James
Murray, Philip I
Rauz, Saaeha
Anxiety and depression in inflammatory eye disease: exploring the potential impact of topical treatment frequency as a putative psychometric item
title Anxiety and depression in inflammatory eye disease: exploring the potential impact of topical treatment frequency as a putative psychometric item
title_full Anxiety and depression in inflammatory eye disease: exploring the potential impact of topical treatment frequency as a putative psychometric item
title_fullStr Anxiety and depression in inflammatory eye disease: exploring the potential impact of topical treatment frequency as a putative psychometric item
title_full_unstemmed Anxiety and depression in inflammatory eye disease: exploring the potential impact of topical treatment frequency as a putative psychometric item
title_short Anxiety and depression in inflammatory eye disease: exploring the potential impact of topical treatment frequency as a putative psychometric item
title_sort anxiety and depression in inflammatory eye disease: exploring the potential impact of topical treatment frequency as a putative psychometric item
topic Vision Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261890/
https://www.ncbi.nlm.nih.gov/pubmed/34307892
http://dx.doi.org/10.1136/bmjophth-2020-000649
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