Cargando…
Chronic obstructive pulmonary disease does not impair responses to resistance training
BACKGROUND: Subjects with chronic obstructive pulmonary disease (COPD) are prone to accelerated decay of muscle strength and mass with advancing age. This is believed to be driven by disease-inherent systemic pathophysiologies, which are also assumed to drive muscle cells into a state of anabolic re...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261934/ https://www.ncbi.nlm.nih.gov/pubmed/34229714 http://dx.doi.org/10.1186/s12967-021-02969-1 |
_version_ | 1783719096328650752 |
---|---|
author | Mølmen, Knut Sindre Hammarström, Daniel Falch, Gunnar Slettaløkken Grundtvig, Morten Koll, Lise Hanestadhaugen, Marita Khan, Yusuf Ahmad, Rafi Malerbakken, Bente Rødølen, Tore Jørgen Lien, Roger Rønnestad, Bent R. Raastad, Truls Ellefsen, Stian |
author_facet | Mølmen, Knut Sindre Hammarström, Daniel Falch, Gunnar Slettaløkken Grundtvig, Morten Koll, Lise Hanestadhaugen, Marita Khan, Yusuf Ahmad, Rafi Malerbakken, Bente Rødølen, Tore Jørgen Lien, Roger Rønnestad, Bent R. Raastad, Truls Ellefsen, Stian |
author_sort | Mølmen, Knut Sindre |
collection | PubMed |
description | BACKGROUND: Subjects with chronic obstructive pulmonary disease (COPD) are prone to accelerated decay of muscle strength and mass with advancing age. This is believed to be driven by disease-inherent systemic pathophysiologies, which are also assumed to drive muscle cells into a state of anabolic resistance, leading to impaired abilities to adapt to resistance exercise training. Currently, this phenomenon remains largely unstudied. In this study, we aimed to investigate the assumed negative effects of COPD for health- and muscle-related responsiveness to resistance training using a healthy control-based translational approach. METHODS: Subjects with COPD (n = 20, GOLD II-III, FEV(1predicted) 57 ± 11%, age 69 ± 5) and healthy controls (Healthy, n = 58, FEV(1predicted) 112 ± 16%, age 67 ± 4) conducted identical whole-body resistance training interventions for 13 weeks, consisting of two weekly supervised training sessions. Leg exercises were performed unilaterally, with one leg conducting high-load training (10RM) and the contralateral leg conducting low-load training (30RM). Measurements included muscle strength (n(variables) = 7), endurance performance (n(variables) = 6), muscle mass (n(variables) = 3), muscle quality, muscle biology (m. vastus lateralis; muscle fiber characteristics, RNA content including transcriptome) and health variables (body composition, blood). For core outcome domains, weighted combined factors were calculated from the range of singular assessments. RESULTS: COPD displayed well-known pathophysiologies at baseline, including elevated levels of systemic low-grade inflammation ([c-reactive protein](serum)), reduced muscle mass and functionality, and muscle biological aberrancies. Despite this, resistance training led to improved lower-limb muscle strength (15 ± 8%), muscle mass (7 ± 5%), muscle quality (8 ± 8%) and lower-limb/whole-body endurance performance (26 ± 12%/8 ± 9%) in COPD, resembling or exceeding responses in Healthy, measured in both relative and numeric change terms. Within the COPD cluster, lower FEV(1predicted) was associated with larger numeric and relative increases in muscle mass and superior relative improvements in maximal muscle strength. This was accompanied by similar changes in hallmarks of muscle biology such as rRNA-content↑, muscle fiber cross-sectional area↑, type IIX proportions↓, and changes in mRNA transcriptomics. Neither of the core outcome domains were differentially affected by resistance training load. CONCLUSIONS: COPD showed hitherto largely unrecognized responsiveness to resistance training, rejecting the notion of disease-related impairments and rather advocating such training as a potent measure to relieve pathophysiologies. Trial registration: ClinicalTrials.gov ID: NCT02598830. Registered November 6th 2015, https://clinicaltrials.gov/ct2/show/NCT02598830 SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12967-021-02969-1. |
format | Online Article Text |
id | pubmed-8261934 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-82619342021-07-07 Chronic obstructive pulmonary disease does not impair responses to resistance training Mølmen, Knut Sindre Hammarström, Daniel Falch, Gunnar Slettaløkken Grundtvig, Morten Koll, Lise Hanestadhaugen, Marita Khan, Yusuf Ahmad, Rafi Malerbakken, Bente Rødølen, Tore Jørgen Lien, Roger Rønnestad, Bent R. Raastad, Truls Ellefsen, Stian J Transl Med Research BACKGROUND: Subjects with chronic obstructive pulmonary disease (COPD) are prone to accelerated decay of muscle strength and mass with advancing age. This is believed to be driven by disease-inherent systemic pathophysiologies, which are also assumed to drive muscle cells into a state of anabolic resistance, leading to impaired abilities to adapt to resistance exercise training. Currently, this phenomenon remains largely unstudied. In this study, we aimed to investigate the assumed negative effects of COPD for health- and muscle-related responsiveness to resistance training using a healthy control-based translational approach. METHODS: Subjects with COPD (n = 20, GOLD II-III, FEV(1predicted) 57 ± 11%, age 69 ± 5) and healthy controls (Healthy, n = 58, FEV(1predicted) 112 ± 16%, age 67 ± 4) conducted identical whole-body resistance training interventions for 13 weeks, consisting of two weekly supervised training sessions. Leg exercises were performed unilaterally, with one leg conducting high-load training (10RM) and the contralateral leg conducting low-load training (30RM). Measurements included muscle strength (n(variables) = 7), endurance performance (n(variables) = 6), muscle mass (n(variables) = 3), muscle quality, muscle biology (m. vastus lateralis; muscle fiber characteristics, RNA content including transcriptome) and health variables (body composition, blood). For core outcome domains, weighted combined factors were calculated from the range of singular assessments. RESULTS: COPD displayed well-known pathophysiologies at baseline, including elevated levels of systemic low-grade inflammation ([c-reactive protein](serum)), reduced muscle mass and functionality, and muscle biological aberrancies. Despite this, resistance training led to improved lower-limb muscle strength (15 ± 8%), muscle mass (7 ± 5%), muscle quality (8 ± 8%) and lower-limb/whole-body endurance performance (26 ± 12%/8 ± 9%) in COPD, resembling or exceeding responses in Healthy, measured in both relative and numeric change terms. Within the COPD cluster, lower FEV(1predicted) was associated with larger numeric and relative increases in muscle mass and superior relative improvements in maximal muscle strength. This was accompanied by similar changes in hallmarks of muscle biology such as rRNA-content↑, muscle fiber cross-sectional area↑, type IIX proportions↓, and changes in mRNA transcriptomics. Neither of the core outcome domains were differentially affected by resistance training load. CONCLUSIONS: COPD showed hitherto largely unrecognized responsiveness to resistance training, rejecting the notion of disease-related impairments and rather advocating such training as a potent measure to relieve pathophysiologies. Trial registration: ClinicalTrials.gov ID: NCT02598830. Registered November 6th 2015, https://clinicaltrials.gov/ct2/show/NCT02598830 SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12967-021-02969-1. BioMed Central 2021-07-06 /pmc/articles/PMC8261934/ /pubmed/34229714 http://dx.doi.org/10.1186/s12967-021-02969-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Mølmen, Knut Sindre Hammarström, Daniel Falch, Gunnar Slettaløkken Grundtvig, Morten Koll, Lise Hanestadhaugen, Marita Khan, Yusuf Ahmad, Rafi Malerbakken, Bente Rødølen, Tore Jørgen Lien, Roger Rønnestad, Bent R. Raastad, Truls Ellefsen, Stian Chronic obstructive pulmonary disease does not impair responses to resistance training |
title | Chronic obstructive pulmonary disease does not impair responses to resistance training |
title_full | Chronic obstructive pulmonary disease does not impair responses to resistance training |
title_fullStr | Chronic obstructive pulmonary disease does not impair responses to resistance training |
title_full_unstemmed | Chronic obstructive pulmonary disease does not impair responses to resistance training |
title_short | Chronic obstructive pulmonary disease does not impair responses to resistance training |
title_sort | chronic obstructive pulmonary disease does not impair responses to resistance training |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261934/ https://www.ncbi.nlm.nih.gov/pubmed/34229714 http://dx.doi.org/10.1186/s12967-021-02969-1 |
work_keys_str_mv | AT mølmenknutsindre chronicobstructivepulmonarydiseasedoesnotimpairresponsestoresistancetraining AT hammarstromdaniel chronicobstructivepulmonarydiseasedoesnotimpairresponsestoresistancetraining AT falchgunnarslettaløkken chronicobstructivepulmonarydiseasedoesnotimpairresponsestoresistancetraining AT grundtvigmorten chronicobstructivepulmonarydiseasedoesnotimpairresponsestoresistancetraining AT kolllise chronicobstructivepulmonarydiseasedoesnotimpairresponsestoresistancetraining AT hanestadhaugenmarita chronicobstructivepulmonarydiseasedoesnotimpairresponsestoresistancetraining AT khanyusuf chronicobstructivepulmonarydiseasedoesnotimpairresponsestoresistancetraining AT ahmadrafi chronicobstructivepulmonarydiseasedoesnotimpairresponsestoresistancetraining AT malerbakkenbente chronicobstructivepulmonarydiseasedoesnotimpairresponsestoresistancetraining AT rødølentorejørgen chronicobstructivepulmonarydiseasedoesnotimpairresponsestoresistancetraining AT lienroger chronicobstructivepulmonarydiseasedoesnotimpairresponsestoresistancetraining AT rønnestadbentr chronicobstructivepulmonarydiseasedoesnotimpairresponsestoresistancetraining AT raastadtruls chronicobstructivepulmonarydiseasedoesnotimpairresponsestoresistancetraining AT ellefsenstian chronicobstructivepulmonarydiseasedoesnotimpairresponsestoresistancetraining |