Cargando…
Association of TyG index and TG/HDL-C ratio with arterial stiffness progression in a non-normotensive population
BACKGROUND: Cross-sectional studies have reported that insulin resistance (IR) is associated with arterial stiffness. However, the relationship between IR and arterial stiffness progression remains unclear. This study aims to evaluate the association of triglyceride glucose (TyG) index and triglycer...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262008/ https://www.ncbi.nlm.nih.gov/pubmed/34229681 http://dx.doi.org/10.1186/s12933-021-01330-6 |
_version_ | 1783719111716503552 |
---|---|
author | Wu, Zhiyuan Zhou, Di Liu, Yue Li, Zhiwei Wang, Jinqi Han, Ze Miao, Xinlei Liu, Xiangtong Li, Xia Wang, Wei Guo, Xiuhua Tao, Lixin |
author_facet | Wu, Zhiyuan Zhou, Di Liu, Yue Li, Zhiwei Wang, Jinqi Han, Ze Miao, Xinlei Liu, Xiangtong Li, Xia Wang, Wei Guo, Xiuhua Tao, Lixin |
author_sort | Wu, Zhiyuan |
collection | PubMed |
description | BACKGROUND: Cross-sectional studies have reported that insulin resistance (IR) is associated with arterial stiffness. However, the relationship between IR and arterial stiffness progression remains unclear. This study aims to evaluate the association of triglyceride glucose (TyG) index and triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio with arterial stiffness progression in a non-normotensive population. METHODS: A total of 1895 prehypertensive (systolic pressure 120–139 mmHg or diastolic pressure 80–90 mmHg) or hypertensive (systolic pressure ≥ 140 mmHg or diastolic pressure ≥ 90 mmHg or using antihypertensive medication) participants were enrolled in 2013 and 2014, and followed until December 31, 2019. Arterial stiffness progression was measured by brachial-ankle pulse wave velocity (baPWV) change (absolute difference between baseline and last follow-up), baPWV change rate (change divided by following years), and baPWV slope (regression slope between examination year and baPWV). RESULTS: During a median follow-up of 4.71 years, we observed an increasing trend of baPWV in the population. There were linear and positive associations of the TyG index and TG/HDL-C ratio with the three baPWV parameters. The difference (95% CI) in baPWV change (cm/s) comparing participants in the highest quartile versus the lowest of TyG index and TG/HDL-C ratio were 129.5 (58.7–200.0) and 133.4 (52.0–214.9), respectively. Similarly, the evaluated baPWV change rates (cm/s/year) were 37.6 (15.3–60.0) and 43.5 (17.8–69.2), while the slopes of baPWV were 30.6 (9.3–51.8) and 33.5 (9.0–58.0). The observed association was stronger in the hypertensive population. CONCLUSION: Our study indicates that the TyG index and TG/HDL-C ratio are significantly associated with arterial stiffness progression in hypertensive population, not in prehypertensive population. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12933-021-01330-6. |
format | Online Article Text |
id | pubmed-8262008 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-82620082021-07-07 Association of TyG index and TG/HDL-C ratio with arterial stiffness progression in a non-normotensive population Wu, Zhiyuan Zhou, Di Liu, Yue Li, Zhiwei Wang, Jinqi Han, Ze Miao, Xinlei Liu, Xiangtong Li, Xia Wang, Wei Guo, Xiuhua Tao, Lixin Cardiovasc Diabetol Original Investigation BACKGROUND: Cross-sectional studies have reported that insulin resistance (IR) is associated with arterial stiffness. However, the relationship between IR and arterial stiffness progression remains unclear. This study aims to evaluate the association of triglyceride glucose (TyG) index and triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio with arterial stiffness progression in a non-normotensive population. METHODS: A total of 1895 prehypertensive (systolic pressure 120–139 mmHg or diastolic pressure 80–90 mmHg) or hypertensive (systolic pressure ≥ 140 mmHg or diastolic pressure ≥ 90 mmHg or using antihypertensive medication) participants were enrolled in 2013 and 2014, and followed until December 31, 2019. Arterial stiffness progression was measured by brachial-ankle pulse wave velocity (baPWV) change (absolute difference between baseline and last follow-up), baPWV change rate (change divided by following years), and baPWV slope (regression slope between examination year and baPWV). RESULTS: During a median follow-up of 4.71 years, we observed an increasing trend of baPWV in the population. There were linear and positive associations of the TyG index and TG/HDL-C ratio with the three baPWV parameters. The difference (95% CI) in baPWV change (cm/s) comparing participants in the highest quartile versus the lowest of TyG index and TG/HDL-C ratio were 129.5 (58.7–200.0) and 133.4 (52.0–214.9), respectively. Similarly, the evaluated baPWV change rates (cm/s/year) were 37.6 (15.3–60.0) and 43.5 (17.8–69.2), while the slopes of baPWV were 30.6 (9.3–51.8) and 33.5 (9.0–58.0). The observed association was stronger in the hypertensive population. CONCLUSION: Our study indicates that the TyG index and TG/HDL-C ratio are significantly associated with arterial stiffness progression in hypertensive population, not in prehypertensive population. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12933-021-01330-6. BioMed Central 2021-07-06 /pmc/articles/PMC8262008/ /pubmed/34229681 http://dx.doi.org/10.1186/s12933-021-01330-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Original Investigation Wu, Zhiyuan Zhou, Di Liu, Yue Li, Zhiwei Wang, Jinqi Han, Ze Miao, Xinlei Liu, Xiangtong Li, Xia Wang, Wei Guo, Xiuhua Tao, Lixin Association of TyG index and TG/HDL-C ratio with arterial stiffness progression in a non-normotensive population |
title | Association of TyG index and TG/HDL-C ratio with arterial stiffness progression in a non-normotensive population |
title_full | Association of TyG index and TG/HDL-C ratio with arterial stiffness progression in a non-normotensive population |
title_fullStr | Association of TyG index and TG/HDL-C ratio with arterial stiffness progression in a non-normotensive population |
title_full_unstemmed | Association of TyG index and TG/HDL-C ratio with arterial stiffness progression in a non-normotensive population |
title_short | Association of TyG index and TG/HDL-C ratio with arterial stiffness progression in a non-normotensive population |
title_sort | association of tyg index and tg/hdl-c ratio with arterial stiffness progression in a non-normotensive population |
topic | Original Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262008/ https://www.ncbi.nlm.nih.gov/pubmed/34229681 http://dx.doi.org/10.1186/s12933-021-01330-6 |
work_keys_str_mv | AT wuzhiyuan associationoftygindexandtghdlcratiowitharterialstiffnessprogressioninanonnormotensivepopulation AT zhoudi associationoftygindexandtghdlcratiowitharterialstiffnessprogressioninanonnormotensivepopulation AT liuyue associationoftygindexandtghdlcratiowitharterialstiffnessprogressioninanonnormotensivepopulation AT lizhiwei associationoftygindexandtghdlcratiowitharterialstiffnessprogressioninanonnormotensivepopulation AT wangjinqi associationoftygindexandtghdlcratiowitharterialstiffnessprogressioninanonnormotensivepopulation AT hanze associationoftygindexandtghdlcratiowitharterialstiffnessprogressioninanonnormotensivepopulation AT miaoxinlei associationoftygindexandtghdlcratiowitharterialstiffnessprogressioninanonnormotensivepopulation AT liuxiangtong associationoftygindexandtghdlcratiowitharterialstiffnessprogressioninanonnormotensivepopulation AT lixia associationoftygindexandtghdlcratiowitharterialstiffnessprogressioninanonnormotensivepopulation AT wangwei associationoftygindexandtghdlcratiowitharterialstiffnessprogressioninanonnormotensivepopulation AT guoxiuhua associationoftygindexandtghdlcratiowitharterialstiffnessprogressioninanonnormotensivepopulation AT taolixin associationoftygindexandtghdlcratiowitharterialstiffnessprogressioninanonnormotensivepopulation |