Cargando…

The Role of Human Papilloma Virus in Dictating Outcomes in Head and Neck Squamous Cell Carcinoma

The Human Papilloma Virus (HPV) is an oncogenic virus which is associated with the development of head and neck squamous cell carcinoma (HNSCC), predominantly within the oropharynx. Approximately 25% of oropharyngeal squamous cell carcinoma (OPSCC) cases worldwide are attributable to HPV infection,...

Descripción completa

Detalles Bibliográficos
Autores principales: Brennan, Shane, Baird, Anne-Marie, O’Regan, Esther, Sheils, Orla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262095/
https://www.ncbi.nlm.nih.gov/pubmed/34250016
http://dx.doi.org/10.3389/fmolb.2021.677900
_version_ 1783719126454239232
author Brennan, Shane
Baird, Anne-Marie
O’Regan, Esther
Sheils, Orla
author_facet Brennan, Shane
Baird, Anne-Marie
O’Regan, Esther
Sheils, Orla
author_sort Brennan, Shane
collection PubMed
description The Human Papilloma Virus (HPV) is an oncogenic virus which is associated with the development of head and neck squamous cell carcinoma (HNSCC), predominantly within the oropharynx. Approximately 25% of oropharyngeal squamous cell carcinoma (OPSCC) cases worldwide are attributable to HPV infection, with an estimated 65% in the United States. Transmission is via exposure during sexual contact, with distinctive anatomical features of the tonsils providing this organ with a predilection for infection by HPV. No premalignant lesion is identifiable on clinical examination, thus no comparative histological features to denote the stages of carcinogenesis for HPV driven HNSCC are identifiable. This is in contrast to HPV-driven cervical carcinoma, making screening a challenge for the head and neck region. However, HPV proffers a favorable prognosis in the head and neck region, with better overall survival rates in contrast to its HPV negative counterparts. This has resulted in extensive research into de-intensifying therapies aiming to minimize the morbidity induced by standard concurrent chemo-radiotherapy without compromising efficacy. Despite the favorable prognosis, cases of recurrence and/or metastasis of HPV positive HNSCC do occur, and are linked with poor outcomes. HPV 16 is the most frequent genotype identified in HNSCC, yet there is limited research to date studying the impact of other HPV genotype with respect to overall survival. A similar situation pertains to genetic aberrations associated in those with HPV positive HNSCC who recur, with only four published studies to date. Somatic mutations in TSC2, BRIP1, NBN, TACC3, NFE2l2, STK11, HRAS, PIK3R1, TP63, and FAT1 have been identified in recurrent HPV positive OPSCC. Finding alternative therapeutic strategies for this young cohort may depend on upfront identification of HPV genotypes and mutations which are linked with worse outcomes, thus ensuring appropriate stratification of treatment regimens.
format Online
Article
Text
id pubmed-8262095
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-82620952021-07-08 The Role of Human Papilloma Virus in Dictating Outcomes in Head and Neck Squamous Cell Carcinoma Brennan, Shane Baird, Anne-Marie O’Regan, Esther Sheils, Orla Front Mol Biosci Molecular Biosciences The Human Papilloma Virus (HPV) is an oncogenic virus which is associated with the development of head and neck squamous cell carcinoma (HNSCC), predominantly within the oropharynx. Approximately 25% of oropharyngeal squamous cell carcinoma (OPSCC) cases worldwide are attributable to HPV infection, with an estimated 65% in the United States. Transmission is via exposure during sexual contact, with distinctive anatomical features of the tonsils providing this organ with a predilection for infection by HPV. No premalignant lesion is identifiable on clinical examination, thus no comparative histological features to denote the stages of carcinogenesis for HPV driven HNSCC are identifiable. This is in contrast to HPV-driven cervical carcinoma, making screening a challenge for the head and neck region. However, HPV proffers a favorable prognosis in the head and neck region, with better overall survival rates in contrast to its HPV negative counterparts. This has resulted in extensive research into de-intensifying therapies aiming to minimize the morbidity induced by standard concurrent chemo-radiotherapy without compromising efficacy. Despite the favorable prognosis, cases of recurrence and/or metastasis of HPV positive HNSCC do occur, and are linked with poor outcomes. HPV 16 is the most frequent genotype identified in HNSCC, yet there is limited research to date studying the impact of other HPV genotype with respect to overall survival. A similar situation pertains to genetic aberrations associated in those with HPV positive HNSCC who recur, with only four published studies to date. Somatic mutations in TSC2, BRIP1, NBN, TACC3, NFE2l2, STK11, HRAS, PIK3R1, TP63, and FAT1 have been identified in recurrent HPV positive OPSCC. Finding alternative therapeutic strategies for this young cohort may depend on upfront identification of HPV genotypes and mutations which are linked with worse outcomes, thus ensuring appropriate stratification of treatment regimens. Frontiers Media S.A. 2021-06-23 /pmc/articles/PMC8262095/ /pubmed/34250016 http://dx.doi.org/10.3389/fmolb.2021.677900 Text en Copyright © 2021 Brennan, Baird, O’Regan and Sheils. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Brennan, Shane
Baird, Anne-Marie
O’Regan, Esther
Sheils, Orla
The Role of Human Papilloma Virus in Dictating Outcomes in Head and Neck Squamous Cell Carcinoma
title The Role of Human Papilloma Virus in Dictating Outcomes in Head and Neck Squamous Cell Carcinoma
title_full The Role of Human Papilloma Virus in Dictating Outcomes in Head and Neck Squamous Cell Carcinoma
title_fullStr The Role of Human Papilloma Virus in Dictating Outcomes in Head and Neck Squamous Cell Carcinoma
title_full_unstemmed The Role of Human Papilloma Virus in Dictating Outcomes in Head and Neck Squamous Cell Carcinoma
title_short The Role of Human Papilloma Virus in Dictating Outcomes in Head and Neck Squamous Cell Carcinoma
title_sort role of human papilloma virus in dictating outcomes in head and neck squamous cell carcinoma
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262095/
https://www.ncbi.nlm.nih.gov/pubmed/34250016
http://dx.doi.org/10.3389/fmolb.2021.677900
work_keys_str_mv AT brennanshane theroleofhumanpapillomavirusindictatingoutcomesinheadandnecksquamouscellcarcinoma
AT bairdannemarie theroleofhumanpapillomavirusindictatingoutcomesinheadandnecksquamouscellcarcinoma
AT oreganesther theroleofhumanpapillomavirusindictatingoutcomesinheadandnecksquamouscellcarcinoma
AT sheilsorla theroleofhumanpapillomavirusindictatingoutcomesinheadandnecksquamouscellcarcinoma
AT brennanshane roleofhumanpapillomavirusindictatingoutcomesinheadandnecksquamouscellcarcinoma
AT bairdannemarie roleofhumanpapillomavirusindictatingoutcomesinheadandnecksquamouscellcarcinoma
AT oreganesther roleofhumanpapillomavirusindictatingoutcomesinheadandnecksquamouscellcarcinoma
AT sheilsorla roleofhumanpapillomavirusindictatingoutcomesinheadandnecksquamouscellcarcinoma