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NOTCH Single Nucleotide Polymorphisms in the Predisposition of Breast and Colorectal Cancers in Saudi Patients

Breast cancer (BC) is a heterogeneous disease and is one of the most common malignancy affecting women worldwide while colorectal cancer (CRC) is estimated to be the third common cancer and second leading cause of cancer related death globally. Both BC and CRC involve multiple genetic and epigenetic...

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Autores principales: Alanazi, Ibrahim O., Shaik, Jilani Purusottapatnam, Parine, Narasimha Reddy, Al Naeem, Abdulrahman, Azzam, Nahla A., Almadi, Majid A., Aljebreen, Abdulrahman M., Alharbi, Othman, Alanazi, Mohammad Saud, Khan, Zahid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262141/
https://www.ncbi.nlm.nih.gov/pubmed/34257585
http://dx.doi.org/10.3389/pore.2021.616204
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author Alanazi, Ibrahim O.
Shaik, Jilani Purusottapatnam
Parine, Narasimha Reddy
Al Naeem, Abdulrahman
Azzam, Nahla A.
Almadi, Majid A.
Aljebreen, Abdulrahman M.
Alharbi, Othman
Alanazi, Mohammad Saud
Khan, Zahid
author_facet Alanazi, Ibrahim O.
Shaik, Jilani Purusottapatnam
Parine, Narasimha Reddy
Al Naeem, Abdulrahman
Azzam, Nahla A.
Almadi, Majid A.
Aljebreen, Abdulrahman M.
Alharbi, Othman
Alanazi, Mohammad Saud
Khan, Zahid
author_sort Alanazi, Ibrahim O.
collection PubMed
description Breast cancer (BC) is a heterogeneous disease and is one of the most common malignancy affecting women worldwide while colorectal cancer (CRC) is estimated to be the third common cancer and second leading cause of cancer related death globally. Both BC and CRC involve multiple genetic and epigenetic alterations in genes belonging to various signaling pathways including NOTCH that has been implicated in the development of these cancers. We investigated four single nucleotide polymorphisms, each in genes encoding NOTCH1-4 receptors for their role in susceptibility to breast and colorectal cancers in Saudi population. In this case-control study, TaqMan genotypic analysis of rs3124591 in NOTCH1 and rs3820041 in NOTCH4 did not exhibit association with breast as well as colorectal cancers. However, a strong association of rs11249433 which is in close proximity to NOTCH2 was observed with breast cancer susceptibility especially with those having an early onset of the disease. Interestingly, the rs1043994 located in NOTCH3 showed gender preference and was found to be significantly associated with colorectal cancers in males. Validation of these findings in bigger populations of different ethnicities may prove beneficial in identifying rs11249433 and rs1043994 as genetic screening markers for early detection of breast and colorectal carcinomas, respectively.
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spelling pubmed-82621412021-07-12 NOTCH Single Nucleotide Polymorphisms in the Predisposition of Breast and Colorectal Cancers in Saudi Patients Alanazi, Ibrahim O. Shaik, Jilani Purusottapatnam Parine, Narasimha Reddy Al Naeem, Abdulrahman Azzam, Nahla A. Almadi, Majid A. Aljebreen, Abdulrahman M. Alharbi, Othman Alanazi, Mohammad Saud Khan, Zahid Pathol Oncol Res Society Journal Archive Breast cancer (BC) is a heterogeneous disease and is one of the most common malignancy affecting women worldwide while colorectal cancer (CRC) is estimated to be the third common cancer and second leading cause of cancer related death globally. Both BC and CRC involve multiple genetic and epigenetic alterations in genes belonging to various signaling pathways including NOTCH that has been implicated in the development of these cancers. We investigated four single nucleotide polymorphisms, each in genes encoding NOTCH1-4 receptors for their role in susceptibility to breast and colorectal cancers in Saudi population. In this case-control study, TaqMan genotypic analysis of rs3124591 in NOTCH1 and rs3820041 in NOTCH4 did not exhibit association with breast as well as colorectal cancers. However, a strong association of rs11249433 which is in close proximity to NOTCH2 was observed with breast cancer susceptibility especially with those having an early onset of the disease. Interestingly, the rs1043994 located in NOTCH3 showed gender preference and was found to be significantly associated with colorectal cancers in males. Validation of these findings in bigger populations of different ethnicities may prove beneficial in identifying rs11249433 and rs1043994 as genetic screening markers for early detection of breast and colorectal carcinomas, respectively. Frontiers Media S.A. 2021-04-09 /pmc/articles/PMC8262141/ /pubmed/34257585 http://dx.doi.org/10.3389/pore.2021.616204 Text en Copyright © 2021 Alanazi, Shaik, Parine, Al Naeem, Azzam, Almadi, Aljebreen, Alharbi, Alanazi and Khan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Society Journal Archive
Alanazi, Ibrahim O.
Shaik, Jilani Purusottapatnam
Parine, Narasimha Reddy
Al Naeem, Abdulrahman
Azzam, Nahla A.
Almadi, Majid A.
Aljebreen, Abdulrahman M.
Alharbi, Othman
Alanazi, Mohammad Saud
Khan, Zahid
NOTCH Single Nucleotide Polymorphisms in the Predisposition of Breast and Colorectal Cancers in Saudi Patients
title NOTCH Single Nucleotide Polymorphisms in the Predisposition of Breast and Colorectal Cancers in Saudi Patients
title_full NOTCH Single Nucleotide Polymorphisms in the Predisposition of Breast and Colorectal Cancers in Saudi Patients
title_fullStr NOTCH Single Nucleotide Polymorphisms in the Predisposition of Breast and Colorectal Cancers in Saudi Patients
title_full_unstemmed NOTCH Single Nucleotide Polymorphisms in the Predisposition of Breast and Colorectal Cancers in Saudi Patients
title_short NOTCH Single Nucleotide Polymorphisms in the Predisposition of Breast and Colorectal Cancers in Saudi Patients
title_sort notch single nucleotide polymorphisms in the predisposition of breast and colorectal cancers in saudi patients
topic Society Journal Archive
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262141/
https://www.ncbi.nlm.nih.gov/pubmed/34257585
http://dx.doi.org/10.3389/pore.2021.616204
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