Perilipin 2 downregulation in β cells impairs insulin secretion under nutritional stress and damages mitochondria

Perilipin 2 (PLIN2) is a lipid droplet (LD) protein in β cells that increases under nutritional stress. Downregulation of PLIN2 is often sufficient to reduce LD accumulation. To determine whether PLIN2 positively or negatively affects β cell function under nutritional stress, PLIN2 was downregulated...

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Detalles Bibliográficos
Autores principales: Mishra, Akansha, Liu, Siming, Promes, Joseph, Harata, Mikako, Sivitz, William, Fink, Brian, Bhardwaj, Gourav, O’Neill, Brian T., Kang, Chen, Sah, Rajan, Strack, Stefan, Stephens, Samuel, King, Timothy, Jackson, Laura, Greenberg, Andrew S., Anokye-Danso, Frederick, Ahima, Rexford S., Ankrum, James, Imai, Yumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262280/
https://www.ncbi.nlm.nih.gov/pubmed/33784258
http://dx.doi.org/10.1172/jci.insight.144341

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