IgV somatic mutation of human anti–SARS-CoV-2 monoclonal antibodies governs neutralization and breadth of reactivity

Abs that neutralize SARS-CoV-2 are thought to provide the most immediate and effective treatment for those severely afflicted by this virus. Because coronavirus potentially diversifies by mutation, broadly neutralizing Abs are especially sought. Here, we report a possibly novel approach to rapid gen...

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Detalles Bibliográficos
Autores principales: de Mattos Barbosa, Mayara Garcia, Liu, Hui, Huynh, Daniel, Shelley, Greg, Keller, Evan T., Emmer, Brian T., Sherman, Emily, Ginsburg, David, Kennedy, Andrew A., Tai, Andrew W., Wobus, Christiane, Mirabeli, Carmen, Lanigan, Thomas M., Samaniego, Milagros, Meng, Wenzhao, Rosenfeld, Aaron M., Prak, Eline T. Luning, Platt, Jeffrey L., Cascalho, Marilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262290/
https://www.ncbi.nlm.nih.gov/pubmed/33769311
http://dx.doi.org/10.1172/jci.insight.147386

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