Loss of diacylglycerol kinase ε causes thrombotic microangiopathy by impairing endothelial VEGFA signaling

Loss of function of the lipid kinase diacylglycerol kinase ε (DGKε), encoded by the gene DGKE, causes a form of atypical hemolytic uremic syndrome that is not related to abnormalities of the alternative pathway of the complement, by mechanisms that are not understood. By generating a potentially nov...

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Detalles Bibliográficos
Autores principales: Liu, Dingxiao, Ding, Qiong, Dai, Dao-Fu, Padhy, Biswajit, Nayak, Manasa K., Li, Can, Purvis, Madison, Jin, Heng, Shu, Chang, Chauhan, Anil K., Huang, Chou-Long, Attanasio, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262293/
https://www.ncbi.nlm.nih.gov/pubmed/33986189
http://dx.doi.org/10.1172/jci.insight.146959

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