Mitochondria-dependent phase separation of disease-relevant proteins drives pathological features of age-related macular degeneration

Age-related macular degeneration (AMD) damages the retinal pigment epithelium (RPE), the tissue that safeguards photoreceptor health, leading to irreversible vision loss. Polymorphisms in cholesterol and complement genes are implicated in AMD, yet mechanisms linking risk variants to RPE injury remai...

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Detalles Bibliográficos
Autores principales: La Cunza, Nilsa, Tan, Li Xuan, Thamban, Thushara, Germer, Colin J., Rathnasamy, Gurugirijha, Toops, Kimberly A., Lakkaraju, Aparna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262309/
https://www.ncbi.nlm.nih.gov/pubmed/33822768
http://dx.doi.org/10.1172/jci.insight.142254

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